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  • J. C. Dodge, Amanda M. Haidet, +14 authors Brian K Kaspar
  • Biology, Medicine
  • Molecular therapy : the journal of the American…
  • 2008 (First Publication: 1 June 2008)
  • Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor system. Recent work in rodent models of ALS has shown that insulin-like growth factor-1 (IGF-1) slows diseaseExpand
  • J. C. Dodge, Christopher M. Treleaven, +8 authors Lamya S. Shihabuddin
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences
  • 2013 (First Publication: 10 June 2013)
  • Metabolic dysfunction is an important modulator of disease course in amyotrophic lateral sclerosis (ALS). We report here that a familial mouse model (transgenic mice over-expressing the G93A mutationExpand
  • S. Pablo Sardi, Jennifer C. Clarke, +11 authors Lamya S. Shihabuddin
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2013 (First Publication: 7 January 2013)
  • Mutations of GBA1, the gene encoding glucocerebrosidase, represent a common genetic risk factor for developing the synucleinopathies Parkinson disease (PD) and dementia with Lewy bodies. PD patientsExpand
  • J. C. Dodge, Christopher M. Treleaven, +10 authors Brian K Kaspar
  • Biology, Medicine
  • Molecular therapy : the journal of the American…
  • 2010 (First Publication: 1 December 2010)
  • Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron cell death in the cortex, brainstem, and spinal cord. Extensive efforts have been made toExpand
  • Lisa M. Stanek, S. Pablo Sardi, +6 authors Lamya S. Shihabuddin
  • Biology, Medicine
  • Human gene therapy
  • 2014 (First Publication: 31 January 2014)
  • Huntington's disease (HD) is a fatal autosomal dominant neurodegenerative disease caused by an increase in the number of polyglutamine residues in the huntingtin (Htt) protein. With theExpand
  • J. C. Dodge, Jennifer Clarke, Christopher M. Treleaven, Tatyana V. Taksir, Lamya S. Shihabuddin
  • Medicine, Biology
  • Experimental Neurology
  • 2009 (First Publication: 1 February 2009)
  • Niemann-Pick A (NPA) disease is a lysosomal storage disorder (LSD) caused by a deficiency in acid sphingomyelinase (ASM) activity. Previously, we showed that the storage pathology in the ASM knockoutExpand
  • Christopher M. Treleaven, Thomas J. Tamsett, +8 authors J. C. Dodge
  • Biology, Medicine
  • Molecular therapy : the journal of the American…
  • 2012 (First Publication: 1 September 2012)
  • Central nervous system (CNS)-directed gene therapy with recombinant adeno-associated virus (AAV) vectors has been used effectively to slow disease course in mouse models of several neurodegenerativeExpand