Christopher Li Hsian Chen

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BACKGROUND Alzheimer's disease (AD) is a neurodegenerative disorder with emerging evidence that it is associated with retinal ganglion cell loss; however, few data exist to establish this association. OBJECTIVE To determine whether macular ganglion cell-inner plexiform layer (GC-IPL) and retinal nerve fiber layer (RNFL), as quantitatively measured by(More)
UNLABELLED Rationale Traditional Chinese Medications(TCM) have been reported to have beneficial effects in stroke patients, but were not rigorously evaluated by GCP standards. Aim This study tests the hypothesis that Neuroaid, a TCM widely used in China post-stroke, is superior to placebo in reducing neurological deficit and improving functional outcome in(More)
AIM To determine the potential of cortisol secretion, in response to a physiological stressor, as a biomarker for centrally active compounds targeting the hypothalamic-pituitary-adrenocortical (HPA) axis. METHODS Cortisol response to hypoglycaemia was measured in 26 healthy males in two stages: firstly to derive an algorithm for individualized, graded(More)
Stroke is Singapore's fourth leading cause of death, with a crude death rate of 40.4/100 000 in 2006, a prevalence of 3.65% and an incidence of 1.8/1000, and is among the top 10 causes of hospitalization. Approximately one-quarter of strokes are hemorrhagic. Hospital care for acute stroke costs about US$5000. Subsidized healthcare is widely available for(More)
The brain is extremely susceptible to focal ischaemia. Following vascular occlusion, a core of severely damaged brain tissue develops, surrounded by an ischaemic penumbra. This potentially-salvageable penumbra may be estimated by advanced neuroimaging techniques, particularly by diffusion-perfusion mismatch. Clinical trials have demonstrated the efficacy of(More)
BACKGROUND The presence of microembolic signals (MES) may indicate an increased risk of recurrent ischemic events in patients with stroke. The optimal management of such patients is uncertain. We report the effect of clopidogrel in addition to aspirin on the number of MES in a series of patients with ischemic stroke and transient ischemic attack (TIA) due(More)
RATIONALE The clinical effects of neuroprotective and/or neurorestorative therapies may vary according to location and size of the ischemic injury. Imaging techniques can be useful in stratifying patients for trials that may be beneficial against particular ischemic lesion characteristics. AIM To test the hypothesis that the efficacy of NeuroAiD compared(More)
Age, year, mean (SD) 67 (61–73) 66 (60.8–73) 68 (61–73) 0.417⁎ Years of education 3 (0–6) 4 (0–8) 3 (0–6) 0.051 Gender Male 139 (60.4%) 74 (66.1%) 65 (55.1%) 0.106 Female 91 (39.6%) 38 (33.9%) 53 (44.9%) Race Chinese 182 (79.1%) 87 (77.7%) 95 (80.5%) 0.298 Malay 26 (11.3%) 11 (9.8%) 15 (12.7%) Indian 22 (9.6%) 14 (12.5%) 8 (6.8%) Previous stroke 46 (20.0%)(More)
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