Christopher Lawrence

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The class Dothideomycetes is one of the largest groups of fungi with a high level of ecological diversity including many plant pathogens infecting a broad range of hosts. Here, we compare genome features of 18 members of this class, including 6 necrotrophs, 9 (hemi)biotrophs and 3 saprotrophs, to analyze genome structure, evolution, and the diverse(More)
Fungal plant pathogens cause serious agricultural losses worldwide. Alternaria arborescens is a major pathogen of tomato, with its virulence determined by the presence of a conditionally dispensable chromosome (CDC) carrying host-specific toxin genes. Genes encoding these toxins are well-studied, however the genomic content and organization of the CDC is(More)
strictly clinical or strictly scientific. They were often a happy combination of the two as Holmes brought his knowledge of basic anatomy, microscopy, physiology, and pathology to bear on the problems presented by clinical neurology. Like its predecessor, this volume reproduces Holmes's papers in facsimile, so the individual papers display a profusion of(More)
Before I read this much awaited book I had intended to write an essay review but having finished it I can only call to mind Tolstoy's famous observation in Anna Karenina that "All happy families resemble one another, but each unhappy family is unhappy in its own way". In other words, to write an essay review requires at least some points of contention and(More)
medicine, but it must be remembered that in its day herbal medicine was conventional medicine. Of more importance, to those having no knowledge of scientific Latin, this new edition will be of great value as primary source material in the medical history of the sixteenth century. This book was a good idea. Writing a history of patient care in the early(More)
Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR and SPINK1 variants were associated with pancreatitis risk. We now report two associations at genome-wide significance identified and(More)
  • Debjani Saha, Ramona Fetzner, Britta Burkhardt, Joachim Podlech, Manfred Metzler, Ha Dang +2 others
  • 2012
Alternaria alternata produces more than 60 secondary metabolites, among which alternariol (AOH) and alternariol-9-methyl ether (AME) are important mycotoxins. Whereas the toxicology of these two polyketide-based compounds has been studied, nothing is known about the genetics of their biosynthesis. One of the postulated core enzymes in the biosynthesis of(More)
English-language account of fossils (Parkinson was a reconciler of palaeontology with the Scriptures), and his Observations on the nature and cure ofgout (1 805)-a work largely derived from personal experience-astutely treated the disease as a constitutional disorder due to excessive acidity. Morris's accounts of Parkinson's medical and scientific ideas are(More)