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Mechanism of action of non-cisplatin type DNA-targeted platinum anticancer agents: DNA interactions of novel acridinylthioureas and their platinum conjugates.
TLDR
The DNA binding of two novel acridinylthioureas, ACR-NH-(CH(2))(2)-C(S)-NHCH(3) (1), and their platinum conjugates 4 and 5-derived from [PtCl(2)(en)]-was studied in cell-free model systems using various physico-chemical and biophysical methods. Expand
Peroxyl radical clocks.
TLDR
This peroxyl radical clock methodology has been successfully applied to determine inhibition and propagation rate constants ranging from 10(0) to 10(7) M(-1) s(-1). Expand
Tetrahydro-1,8-naphthyridinol analogues of alpha-tocopherol as antioxidants in lipid membranes and low-density lipoproteins.
Recently we demonstrated that the C(7)-unsubstituted tetrahydro-1,8-naphthyridin-3-ol has more than an order of magnitude better peroxyl radical trapping activity than alpha-tocopherol (alpha-TOH) inExpand
Preparation and investigation of vitamin B6-derived aminopyridinol antioxidants.
TLDR
High-yielding, large-scale syntheses of mono- and bicyclic aminopyridinols from pyridoxine hydrochloride are reported, providing straightforward, scaleable access to novel, potent, molecular scaffolds whose antioxidant properties have been investigated in homogeneous solutions and in liposomal vesicles. Expand
Peroxidation of polyunsaturated fatty acid methyl esters catalyzed by N-methyl benzohydroxamic acid: a new and convenient method for selective synthesis of hydroperoxides and alcohols.
TLDR
A new catalytic system, based on N-methyl benzohydroxamic acid (NMBHA), was developed for the selective synthesis of lipid hydroperoxides and alcohols by aerobic oxidation of lipid precursors with high selectivity to oxidations catalyzed by this reagent. Expand
Substituent effects on regioselectivity in the autoxidation of nonconjugated dienes.
TLDR
Group at C-1 and C-5 of the diene can influence product distribution based upon steric demand in the oxygen-radical reaction and the influence of substituents on the rearrangement of the C-3 peroxyl radical to give conjugated diene products. Expand
Pyridoxine-derived bicyclic aminopyridinol antioxidants: synthesis and their antioxidant activities.
TLDR
Antioxidant activities were measured by a radical clock method and new compounds prepared are comparable to the best bicyclic aminopyridinol antioxidants. Expand
Determination of leukotriene A4 stabilization by S100A8/A9 proteins using mass spectrometry
TLDR
A new liquid chromatography mass spectrometry technique was developed to improve upon previous assays that analyzed LTA4 directly and it was determined that the S100A8/A9 protein complex protects L TA4 from hydrolysis in a Ca2+ dependent manner and increases LTA 4 half-life to in excess of 35 and 5 min at 4°C and 37°C, respectively. Expand
Identification of the peroxidation products of 13-hydroxy-gamma-linolenate and 15-hydroxyarachidonate: mechanistic studies on the formation of leukotriene-like diols.
TLDR
A mechanism for the formation of the dihydroxylinolenates is proposed based on product analysis of oxidations using varied concentrations of alpha-tocopherol. Expand
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