Christopher L. Connell

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The problem of relating volume to degree for maps between Riemannian manifolds is a fundamental one. Gromov’s Volume Comparison Theorem [Gr] gives such a relation for maps into negatively curved manifolds. In this paper we extend Gromov’s theorem to locally symmetric manifolds of nonpositive curvature. We derive this as a consequence of the following(More)
Chronic administration of ciglitazone (5-4[1-methyl-cyclohexylmethoxy)-benzyl]-thiazolidine-2,4 dione) decreased both plasma glucose and insulin concentrations in ob/ob mice. When given as an admixture to the feed, blood glucose levels were reduced as early as 12 hours after initiation of treatment. Concomitant with the decrease in circulating insulin,(More)
The splenic pancreas of 165 day old diabetic KKAy and age-matched nondiabetic C57BL/ 6 mice was examined by morphometry and immunocytochemistry at the light microscopic level and by radioimmunoassay to evaluate the morphology, surface area, endocrine cell composition and hormone content of the pancreatic islets. The insulin cells of the diabetic mice were(More)
Xerostomia, the subjective complaint of dry mouth, and hyposalivation remain a significant burden for many individuals. Diagnosis of xerostomia and salivary gland hypofunction is dependent upon a careful and detailed history and thorough oral examination. There exist many options for treatment and symptom management: salivary stimulants, topical agents,(More)
Platelet aggregation was measured in rat and human platelet-rich plasma (PRP) after the addition of various amounts of arachidonic acid (AA), prostaglandin H2 (PGH2), adenosine diphosphate (ADP), or collagen. AA but not PGH2 caused rat platelets to aggregate in citrated or heparinized PRP. Both AA and PGH2 produced significant amounts of thromboxane A2(More)
The renal tissue of 12-, 29-, 90- and 165-day-old genetically obese, hyperphagic, diabetic KKAy and age-matched nondiabetic C57BL/6 mice was morphometrically analyzed to characterize the development of peripheral glomerular capillary basement membrane thickening in the kidney of this animal model. Peripheral glomerular basement membrane (GBM) thickness was(More)
The performance and success of many self-timed design methodologies commonly rely heavily on completion detection schemes in order to reliably acknowledge the termination of a computation associated with a self-timed functional block. A particularly vexing problem associated with many self-timed completion detection schemes proposed in the literature, is(More)
BACKGROUND Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas two of B100 common, low-penetrance PrCa susceptibility variants identified so far by genome-wide association studies implicate RAD51B(More)
where B(x,R) is the ball of radius R around a fixed point x in the universal cover X. (For noncompact M , see Section 6.2.) The number h(g) is independent of the choice of x, and equals the topological entropy of the geodesic flow on (M, g) when the curvature K(g) satisfies K(g) ≤ 0 (see [Ma]). Note that while the volume Vol(M, g) is not invariant under(More)