Christopher Kamel

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The NAD-dependent deacetylase SIR2 and the forkhead transcription factor DAF-16 regulate lifespan in model organisms, such as yeast and C. elegans. Here we show that the mammalian SIR2 ortholog SIRT1 deacetylates and represses the activity of the forkhead transcription factor Foxo3a and other mammalian forkhead factors. This regulation appears to be in the(More)
The SirT1 gene encodes a protein deacetylase that acts on a number of nuclear substrates. p53 was identified as a SirT1 substrate whose transcriptional activity was reported to be negatively regulated by SirT1-dependent deacetylation. We set out to determine whether developmental defects and perinatal lethality observed in SirT1-null mice were caused by p53(More)
Estimation of the energy value of a ration is fundamental for the determination of the quantity required to meet the energy requirement of the animal. Net Energy is the best estimate of the energy value of a feed/ration, but is difficult, time consuming and costly to determine. In addition, it is virtually impossible to measure the energy value of a single(More)
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