Christopher K. Tison

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Stem cell response to a library of scaffolds with varied 3D structures was investigated. Microarray screening revealed that each type of scaffold structure induced a unique gene expression signature in primary human bone marrow stromal cells (hBMSCs). Hierarchical cluster analysis showed that treatments sorted by scaffold structure and not by polymer(More)
Many scaffold systems have evolved for tissue engineering and in vitro tissue models to provide a 3D (three-dimensional) microenvironment that enables cells to behave more physiologically. We hypothesized that cells would adopt morphologies with more 3D character during culture in scaffolds as compared to planar substrates. Cell shape and function are(More)
We have designed a 2-spinnerette device that can directly electrospin nanofiber scaffolds containing a gradient in composition that can be used to engineer interfacial tissues such as ligament and tendon. Two types of nanofibers are simultaneously electrospun in an overlapping pattern to create a nonwoven mat of nanofibers containing a composition gradient.(More)
There is a need for tools to classify cells based on their 3D shape. Cells exist in vivo in 3D, cells are frequently cultured within 3D scaffolds in vitro, and 3D scaffolds are used for cell delivery in tissue engineering therapies. Recent work indicates that the physical structure of a tissue engineering scaffold can direct stem cell function by driving(More)
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