Christopher K. R. T. Jones

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The first structure of a flavivirus has been determined by using a combination of cryoelectron microscopy and fitting of the known structure of glycoprotein E into the electron density map. The virus core, within a lipid bilayer, has a less-ordered structure than the external, icosahedral scaffold of 90 glycoprotein E dimers. The three E monomers per(More)
We derive a model for the propagation of short pulses in nonlinear media. The model is a higher order regularization of the short pulse equation (SPE). The regularization term arises as the next term in the expansion of the susceptibility in derivation of the SPE. Without the regularization term there do not exist traveling pulses in the class of piecewise(More)
The type I interferon response protects cells against invading viral pathogens. The cellular factors that mediate this defence are the products of interferon-stimulated genes (ISGs). Although hundreds of ISGs have been identified since their discovery more than 25 years ago, only a few have been characterized with respect to antiviral activity. For most ISG(More)
Hepatitis C virus (HCV), which infects 2-3% of the world population, is a causative agent of chronic hepatitis and the leading indication for liver transplantation. The ability to propagate HCV in cell culture (HCVcc) is a relatively recent breakthrough and a key tool in the quest for specific antiviral therapeutics. Monitoring HCV infection in culture(More)
The electrical dynamics in the heart is modeled by a two-component PDE. Using geometric singular perturbation theory, it is shown that a traveling pulse solution, which corresponds to a single heartbeat, exists. One key aspect of the proof involves tracking the solution near a point on the slow manifold that is not normally hyperbolic. This is achieved by(More)
  • M Sultan, A Wagdy, N Manocha, W Sauck, K Abdel Gelil, A F Youssef +4 others
  • 2008
KEYWORDS Assessment of groundwater resources; Arid land hydrology; Transcurrent fault systems Summary Groundwater potentials were assessed for major transcurrent fault systems in basement complex terrains using the Najd transcurrent Shear System of the Arabian Nubian Shield as a test case. Spatial analysis, within a geographical information system(More)
The evolution of optical pulses in fiber optic communication systems with strong, higher order dispersion management is modeled by a cubic nonlinear Schrödinger equation with periodically varying linear dispersion at second and third order. Through an averaging procedure, we derive an approximate model for the slow evolution of such pulses, and show that(More)
Hepatitis C virus (HCV) remains a major medical problem. Antiviral treatment is only partially effective and a vaccine does not exist. Development of more effective therapies has been hampered by the lack of a suitable small animal model. Although xenotransplantation of immunodeficient mice with human hepatocytes has shown promise, these models are subject(More)
Hepatitis C virus (HCV) remains a major public health problem, affecting approximately 130 million people worldwide. HCV infection can lead to cirrhosis, hepatocellular carcinoma, and end-stage liver disease, as well as extrahepatic complications such as cryoglobulinemia and lymphoma. Preventative and therapeutic options are severely limited; there is no(More)