Christopher J. Webster

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This paper is intended to stimulate debate amongst stakeholders in the international research community on the topic of returning individual genetic research results to study participants. Pharmacogenetics and disease genetics studies are becoming increasingly prevalent, leading to a growing body of information on genetic associations for drug(More)
The flow of new medicines to patients depends on the development of new biomarkers and their correct interpretation, yet there are no widely accepted and practically applicable criteria that facilitate adequate biomarker qualification. As a result, case-by-case qualifications are based on subjective assessments that do not lead to optimal decisions for(More)
Part 1 of this two-part paper presented a spatial economic model of the urban development process which captures developers' profit-seeking behaviour, communities' welfare-seeking behaviour, and the mediating effects of alternative systems of land-use rights. Different systems of rights were shown to result in different land-use and density outcomes. In(More)
This paper reports on an attempt to combine neo-classical urban economic theory with complex systems methods. The innovative feature of our model from the point of view of conventional economic theory lies in its explicit treatment of spatial relationships and time sequence. From the perspective of raster or cellular GIS models of urban processes, the work(More)
BACKGROUND Symptoms referable to the sinus area are frequently reported during migraine attacks, but are not recognized in diagnostic criteria. Underrecognition of migraine may be partly attributed to a variable clinical presentation, and migraines with "sinus" symptoms contribute to this problem. This study was conducted to determine the prevalence of(More)
This double-blind, placebo-controlled, multicenter, crossover study investigated the efficacy and tolerability of sumatriptan administered for up to three separate migraine attacks. One hundred twenty adults received sumatriptan (SC, 6 mg; three attacks) and placebo (one attack). Patients completed questionnaires assessing the impact of migraine on their(More)
OBJECTIVE This 1-year, open-label, multicenter study was designed to assess the long-term tolerability and efficacy of sumatriptan nasal spray 20 mg in adolescent patients with migraine. METHODS A prospective, multicenter, open-label study was conducted in patients aged 12 to 17 years who were allowed to treat an unlimited number of migraines at severe,(More)
"To increase the utility of satellite imagery as a source of cheap and current information for planning and managing cities some problems have to be resolved.... One answer is to adopt interpretation methods that use the increased information in a more detailed scene. This paper reports on attempts to measure the morphological patterns in an urban satellite(More)
BACKGROUND Many patients and physicians interpret episodic headache in the presence or absence of nasal symptoms as "sinus' headache, while ignoring the possible diagnosis of migraine. OBJECTIVE The purpose of this study was to assess the efficacy and tolerability of sumatriptan succinate 50-mg tablets in patients with migraine presenting with "sinus"(More)
Without patent protection, biomedical progress would be severely diminished. Conditions under the current patent regime are characterized by rapid advancement made possible by cooperative licensing, collaboration and partnerships between and among various entities, and the drive to bring successful products to market both in order to make profits and to(More)