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OBJECTIVE To construct a readily applicable formula for selecting patients with systemic sclerosis (SSc) for right-sided heart catheterization (RHC) based on the results of their pulmonary function tests (PFTs). METHODS The diagnostic value of PFT variables was quantified in 386 patients with SSc against data obtained from RHC. RESULTS We derived the(More)
Pulmonary arterial hypertension (PAH) is a progressive disease with poor survival outcomes. Bosentan is an oral endothelin-1 receptor antagonist (ERA) that has been shown in a large randomized placebo-controlled trial (BREATHE-1) to be effective at improving exercise tolerance in patients with PAH in functional class III and IV. Further studies have been(More)
BACKGROUND Dietary intake of fish rich in omega-3 fatty acids is associated with a reduction in cardiovascular events. The mechanisms for this are uncertain and previous studies investigating effects on platelet function have produced inconsistent results. Platelet-monocyte aggregation is a sensitive marker of platelet activation and may contribute to the(More)
OBJECTIVE To determine whether patients with systemic sclerosis (SSc) and borderline mean pulmonary artery pressure (PAP) at cardiac catheterization are more likely to develop pulmonary hypertension (PH) than those in whom pulmonary pressure is normal. METHODS Patients with SSc in whom PH and significant interstitial lung disease had been excluded at(More)
To provide an overview of the properties of human serum albumin (HSA), and to review the evidence for the use of human albumin solution (HAS) in critical illness, sepsis and cirrhosis. A MEDLINE search was performed using the terms "human albumin", "critical illness", "sepsis" and "cirrhosis". The references of retrieved articles were reviewed manually.(More)
OBJECTIVES To report outcomes in patients with CTD-pulmonary arterial hypertension (CTD-PAH) in an observational cohort treated with bosentan or sitaxentan and determine whether differences would justify a randomized, controlled multicentre study in this subpopulation. METHODS Patients with CTD-PAH, diagnosed by right-heart catheter studies, were assigned(More)
heterodimer. A basis for new therapeutic strategies. J Exp Med 2001;193:827–38. 60. Nakajima A, Katayama K, Mayumi T. [PPARgammagene therapy using an adenovirus vector for inflammatory bowel disease]. Nippon Yakurigaku Zasshi 2003;122:309–16. 61. Katayama K, Wada K, Nakajima A, et al. A novel PPAR gamma gene therapy to control inflammation associated with(More)
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