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OBJECTIVE To compare the Routine Assessment of Patient Index Data 3 (RAPID3) on a Multidimensional Health Assessment Questionnaire (MDHAQ) with the Disease Activity Score (DAS28), Clinical Disease Activity Index (CDAI), and individual core data set measures for correlations, agreement of activity levels, and time to score. METHODS Four rheumatologists(More)
BACKGROUND Treatment with statins reduces infarct volume in animal models of ischemic stroke, independently of the effect on cholesterol. This study examined this effect in humans by testing whether patients taking statins at onset of ischemic stroke had smaller infarct volumes than those not taking statins. METHODS The study design was a retrospective(More)
OBJECTIVE To analyse patients with rheumatoid arthritis, treated with methotrexate in a weekly academic rheumatology clinic over 13 years, for continuation of courses and reasons for discontinuation. METHODS All 248 patients with an analysable longitudinal course who took methotrexate in standard care between 1990 and 2003 were studied. Continuation of(More)
Data are often encountered that fail the normality assumption, creating a dilemma between implementing the most appropriate analysis while maintaining appropriate inference. A recent extension of generalized linear models includes support for the Beta distribution, a flexible and accommodating distribution. SAS® can implement " Beta Regression " through(More)
OBJECTIVE Caffeine use is negatively associated with the risk of developing Parkinson disease (PD) and is protective in animal models of PD, but the relationship between caffeine intake and rate of progression of PD is unknown. We assessed this relationship using data from 2 recent clinical trials of PD. METHODS Data were ascertained from 2 recent 1-year(More)
OBJECTIVE To assess the predictive value of baseline measures of impairment, disability, and quality of life for the timing of initiation of symptomatic treatment in early Parkinson disease (PD). DESIGN Inception cohort analysis. SETTING Ambulatory population from multiple sites in the United States and Canada. PARTICIPANTS Four hundred thirteen(More)
CONTEXT Little is known about research participants' understanding of consent information over the course of a clinical study and the relationship of this information with participant behavior. METHODS We conducted a cross sectional patient completed questionnaire of comprehension and satisfaction administered at the end of a Parkinson's disease clinical(More)
OBJECTIVE A randomised double-blind placebo controlled withdrawal clinical trial of prednisone versus placebo in patients with rheumatoid arthritis (RA), treated in usual clinical care with 1-4 mg/day prednisone, withdrawn to the same dose of 1 mg prednisone or identical placebo tablets. METHODS All patients were from one academic setting and all trial(More)
OBJECTIVES The new 2010 American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria for rheumatoid arthritis (RA) have been designed to classify early onset RA, but has not been studied to identify RA in patients with arthritis seen in routine clinical care where correct 'classification' of patients, when they are not selected(More)