Christopher J Passero

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Acid-sensing ion channels are proton-gated Na(+) channels expressed predominantly in neurons. How channel structure translates an environmental stimulus into changes in pore permeability remains largely undefined. The pore of ASIC1 is defined by residues in the second transmembrane domain (TM2), although a segment of the outer vestibule is formed by(More)
Investigations of signal transmission in the auditory system are being carried out in cooperation with the Eaton-Peabody Laboratory for Auditory Physiology at the Massachusetts Eye and Ear Infirmary. The long-term objective is to determine the anatomical structures and physiological mechanisms that underlie vertebrate hearing and to apply that knowledge to(More)
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