Christopher J. P. Newton

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The purpose of this study was to develop and test a topical ocular delivery system for the immunosuppressive drug cyclosporine. To this end, cyclosporine was dissolved in the penetration enhancer, Azone, and applied topically to allografted rabbit eyes. The concentration of cyclosporine in the cornea, the aqueous humor, and blood of the treated rabbits was(More)
This study was performed to compare the soft tissue movements in facial profile predicted by a computer package with those that had actually occurred following a maxillary advancement osteotomy. The source of the material was serial lateral cephalograms for 25 consecutive patients who had received similar Le Fort I osteotomies primarily to correct an(More)
The incidence and severity of extraocular muscle imbalance after conventional scleral buckling surgery was determined for 70 eyes of 68 patients with primary rhegmatogenous retinal detachment. Fifty-eight eyes had circumferential silicone explants, 10 eyes had radial sponges and 2 had both. Sixty-five per cent of eyes showed some restriction of ocular(More)
This study was performed to compare soft tissue movements resulting from a series of Le Fort I osteotomies with those predicted for the same cases by means of a computerised software package (COG 3.4). The source material consisted of serial lateral cephalometric radiographs for 25 consecutive patients that had received similar Le Fort I osteotomies(More)
BACKGROUND Evidence from randomized trials suggests that pain relief during oocyte retrieval is superior when adjunctive paracervical block is used in addition to sedation alone. Vaginal application of lidocaine gel is a non-invasive alternative to lidocaine paracervical block. The goal of the present trial was to compare analgesia with lidocaine vaginal(More)
liquid crystals, bistability, topological classification Bistable director configurations are of great interest in liquid crystal display technologies, offering the possibility of higher resolution combined with reduced power consumption. One way to achieve such bistability is to use the cell geometry. As part of an ongoing programme to analyze quasi-stable(More)
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