Christopher J. Lindsell

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BACKGROUND Anti-epileptic drugs are commonly used for seizure prophylaxis after neurological injury. We performed a study comparing intravenous (IV) levetiracetam (LEV) to IV phenytoin (PHT) for seizure prophylaxis after neurological injury. METHODS In this prospective, single-center, randomized, single-blinded comparative trial of LEV versus PHT (2:1(More)
Functional magnetic resonance imaging (fMRI) has the potential to replace the intracarotid amobarbital procedure (IAP) in presurgical evaluation of patients with epilepsy. In this study, we compared fMRI verb generation (VG) and semantic decision/tone decision (SDTD) tasks and the IAP in their ability to localize language functions in patients with epilepsy(More)
OBJECTIVES To assist occupational health professionals to interpret the results of standardised tests for components of the hand-arm vibration syndrome by presenting data for healthy subjects and identifying the effects of some of the confounding variables. METHOD Thermal thresholds, vibrotactile thresholds, the finger skin temperature (FST) response to(More)
OBJECTIVES To compare vibrotactile thresholds between five international test centres, to determine causes of variability, and to provide normative data for use by health professionals. METHODS Vibrotactile thresholds were measured on various fingers in 1,008 subjects at 31.5 Hz (2,531 measurements) and at 125 Hz (2,807 measurements). Three centres used(More)
INTRODUCTION The intrinsic heterogeneity of clinical septic shock is a major challenge. For clinical trials, individual patient management, and quality improvement efforts, it is unclear which patients are least likely to survive and thus benefit from alternative treatment approaches. A robust risk stratification tool would greatly aid decision-making. The(More)
OBJECTIVE To determine whether interindividual heterogeneity in the erythrocyte (red blood cell [RBC]) transmembrane glucose gradient might explain discordances between A1C and glycemic control based on measured fructosamine. RESEARCH DESIGN AND METHODS We modeled the relationship between plasma glucose and RBC glucose as the concentration distribution(More)
High-dose hydroxymethylglutaryl coenzyme. A reductase inhibitor (statin) administration reduces neuronal injury and improves outcomes in experimental models of acute ischemic stroke, and has been shown to be safe in a phase 1 dose-escalation study using lovastatin at doses higher than currently approved for daily use. Statins also affect the hemostatic(More)
BACKGROUND We previously derived and validated a risk model to estimate mortality probability in children with septic shock (PERSEVERE; PEdiatRic SEpsis biomarkEr Risk modEl). PERSEVERE uses five biomarkers and age to estimate mortality probability. After the initial derivation and validation of PERSEVERE, we combined the derivation and validation cohorts(More)
OBJECTIVE To test the existence of sex differences in cortical activation during verb generation when performance is controlled for. METHODS Twenty male and 20 female healthy adults underwent functional magnetic resonance imaging (fMRI) using a covert block-design verb generation task (BD-VGT) and its event-related version (ER-VGT) that allowed for(More)
Continuous electroencephalography (cEEG) is increasingly used to detect both clinical and subclinical seizures in patients with traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH). We assess whether EEG findings predict outcomes in TBI/SAH patients enrolled in a levetiracetam (LEV) vs. fosphenytoin (fos-PHT) seizure prevention trial (NCT00618436).(More)