Christopher J. Coomber

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A detailed kinetic model of the Ca2+/calmodulin-dependent protein kinase II (CaMKII) is presented in which subunits undergo autophosphorylation at several sites in a manner that depends on the frequency and duration of Ca2+ spikes. It is shown that high-frequency stimulation causes autophosphorylation of the autonomy site (Thr286), and promotes persistent(More)
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is concentrated in brain, and is particularly enriched in synaptic structures where it comprises 20-50% of all proteins. The abundant nature of CaMKII and its ability to phosphorylate a wide range of substrate proteins, including itself, earmarks it as a protein kinase that may have a vital role in(More)
In this paper, we introduce an abbreviated compartmental modelling scheme which may be of interest to those in neuron- based adaptive systems because of the additional scope it provides for studying biologically-inspired learning mechanisms. The scheme, although not as flexible and precise as the general compartmental approach, allows one to design(More)
The specification of delay-insensitive, asynchronous circuits can be undertaken in a variety of ways. Two methods discussed in this paper involve Trace Theory and Signal Transition Graphs. Trace Theory is used to describe the behavior of circuits in terms of sequences (or traces) of signals. These traces can be composed to express cooperative behavior.(More)
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