Christopher J. Barnes

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Lipid peroxidation products can be cytotoxic. Our objectives were (1) to use two pro-oxidants (iron and a pro-oxidative drug) to selectively increase lipid peroxidation in the implanted human breast tumours of mice consuming fish oil and (2) to kill the cancer cells without harming normal host tissues. The theoretical basis for selective cytotoxicity is(More)
Oestrogen receptor (ER) is a good prognostic marker for the treatment of breast cancers. Upregulation of metastatic tumour antigen 1 (MTA1) is associated with the invasiveness and metastatic potential of several human cancers and acts as a co-repressor of nuclear ER-alpha. Here we identify a naturally occurring short form of MTA1 (MTA1s) that contains a(More)
Much research effort has been directed toward understanding how estrogen [17beta-estradiol (E2)] regulates cell proliferation and motility through the rapid, direct activation of cytoplasmic signaling cascades (i.e. nongenomic signaling). Cell migration is critical to cancer cell invasion and metastasis and involves dynamic filamentous actin cytoskeletal(More)
Sustained use of non-steroidal anti-inflammatory drugs (NSAIDs) may prevent colorectal cancer. However, the optimal drug, period of efficacy and mechanism(s) of action are unknown. Experiments were undertaken to determine which of several NSAIDs would modulate colon crypt cell proliferation or apoptosis when given during the initiation phase of(More)
To determine the effects of age, sex, and arm dominance on shoulder range of motion, we measured active and passive forward elevation, abduction, internal and external rotation at 90 degrees of abduction, external rotation with the arm adducted, and extension bilaterally in 280 subjects ranging in age from 4 to 70 years. Linear regression analyses were(More)
  • C J Barnes, G F Dalgleish, E M Jared, K G Swift, S J Tate
  • 2001
Historically, Design For Assembly (DFA) has always been a reactive tool, most often carried out on products in production and, at best, late on in the product introduction process. Thus, a more proactive approach is required. This paper proposes the use of an assembly sequence model as the focus of such a computer-based DFA tool, which would support the(More)
OBJECTIVES To assess activation of muscles of hip adduction using EMG and force analysis during standard clinical tests, and compare athletes with and without a prior history of groin pain. STUDY DESIGN Controlled laboratory study. PARTICIPANTS 21 male athletes from an elite junior soccer program. MAIN OUTCOME MEASURES Bilateral surface EMG recordings(More)
The feel of films, wrapping paper, cardboards, and other packaging materials are important to the commercial success of foods. It is known from people's self-report studies that different surfaces provoke different subjective responses. There are several mechanical parameters, including friction, roughness, compliance, and thermal properties, which are(More)
The optimisation of heat transfer between fluid and metal plays a crucial role in gas turbine design. An accurate prediction of temperature for each metal component can help to minimise the coolant flow requirement, with a direct reduction of the corresponding loss in the thermodynamic cycle. Traditionally, in industry fluid and solid simulations are(More)
BACKGROUND Hospital length of stay (LOS) and time for a patient to reach clinical stability (TCS) have increasingly become important outcomes when investigating ways in which to combat Community Acquired Pneumonia (CAP). Difficulties arise when deciding how to handle in-hospital mortality. Ad-hoc approaches that are commonly used to handle time to event(More)