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The larger isoform of the enzyme glutamate decarboxylase, GAD67, synthesizes >90% of basal levels of gamma-aminobutyric acid (GABA) in the brain. In contrast, the smaller isoform, GAD65, has been implicated in the fine-tuning of inhibitory neurotransmission. Mice deficient in GAD65 exhibit increased anxiety-like responses in both the open field and elevated(More)
  • Colin C Ry, A B Stewart, +4 authors Coltn C Stewart
  • 2004
I N a series of papers dealing with the laws of growth Minot 1 has pointed out the significance of experiments on organisms as individual wholes, as leading toward the proper object and final purpose of biological investigation,-the discovery of the laws of life. Growth, anabolic and accumulating, has its reverse in all forms of katabolism, of which by far(More)
Refractive outcomes following cataract surgery in patients that have previously undergone laser refractive surgery have traditionally been underwhelming. This is related to several key issues including the preoperative assessment (keratometry) and intraocular lens power calculations. Peer-reviewed literature is overwhelmed by the influx of methodology to(More)
Organ Culture corneal storage offers an extended storage time and increased donor pool and tissue assessment opportunities. In September 2011, the Lions New South Wales Eye Bank (LNSWEB) moved from hypothermic storage to Organ Culture corneal storage. This study evaluates the impact of implementation of Organ Culture on donor eye retrieval and the corneal(More)
Scleral tissue has been in use in ophthalmology for many years although indications for use have varied. We retrospectively reviewed scleral transplant tissue requests over a 12 month period at a local eye bank and confirmed a small but significant demand for the use of scleral tissue. Iatrogenic surgical complications are the primary indication for use.(More)
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