Christopher H. Emfinger

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Cholesteryl ester transfer protein (CETP) shuttles lipids between lipoproteins, culminating in cholesteryl ester delivery to liver and increased secretion of cholesterol as bile. Since gut bile acids promote insulin sensitivity, we aimed to define if CETP improves insulin sensitivity with high-fat feeding. CETP and nontransgenic mice of both sexes became(More)
The development of insulin resistance in the liver is a key event that drives dyslipidemia and predicts diabetes and cardiovascular risk with obesity. Clinical data show that estrogen signaling in males helps prevent adiposity and insulin resistance, which may be mediated through estrogen receptor-α (ERα). The tissues and pathways that mediate the benefits(More)
Mechanisms underlying changes in HDL composition caused by obesity are poorly defined, partly because mice lack expression of cholesteryl ester transfer protein (CETP), which shuttles triglyceride and cholesteryl ester between lipoproteins. Because menopause is associated with weight gain, altered glucose metabolism, and changes in HDL, we tested the effect(More)
Type 2 diabetes is characterized by insulin resistance, hyperglycemia, and progressive β cell dysfunction. Excess glucose and lipid impair β cell function in islet cell lines, cultured rodent and human islets, and in vivo rodent models. Here, we examined the mechanistic consequences of glucotoxic and lipotoxic conditions on human islets in vivo and(More)
Recovery of functional β-cell mass continues to be an ongoing challenge in treating diabetes. Initial work studying β-cells suggested apoptotic β-cell death as a main contributor for the loss of β-cell mass in diabetes. Restoration of β-cells either by transplant or stimulating proliferation of remaining β-cells or precursors would then logically be a(More)
ATP-sensitive potassium channels (KATP channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, KATP channels are essential for coupling glucose metabolism to insulin secretion. While orthologous genes for many components of metabolism-secretion coupling in mammals are present in lower vertebrates, their expression, functionality(More)
Estrogen signaling prevents diet-induced hepatic insulin resistance 1 in male mice with obesity. 2 3 4 5 6 Lin Zhu , Melissa N. Martinez , Christopher H. Emfinger , Brian T. Palmisano , and 7 John M. Stafford * 8 9 1 Tennessee Valley Healthcare System, 2 Division of Diabetes, Endocrinology, & 10 Metabolism, Department of Internal Medicine, 3 Department of(More)
Expression and function of ATP-dependent potassium channels in zebrafish islet β-cells." Royal function of ATP-dependent potassium channels in zebrafish islet β-cells. ATP-sensitive potassium channels (K ATP channels) are critical nutrient sensors in many mammalian tissues. In the pancreas, K ATP channels are essential for coupling glucose metabolism to(More)
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