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BACKGROUND Long-term retention of patients in Africa's rapidly expanding antiretroviral therapy (ART) programs for HIV/AIDS is essential for these programs' success but has received relatively little attention. In this paper we present a systematic review of patient retention in ART programs in sub-Saharan Africa. METHODS AND FINDINGS We searched Medline,(More)
BACKGROUND Adherence to highly active antiretroviral therapy (HAART) medication is the greatest patient-enabled predictor of treatment success and mortality for those who have access to drugs. We systematically reviewed the literature to determine patient-reported barriers and facilitators to adhering to antiretroviral therapy. METHODS AND FINDINGS We(More)
Multicore processors are becoming ubiquitous, and it is becoming increasingly common to run multiple real-time systems on a shared multicore platform. While this trend helps to reduce cost and to increase performance, it also makes it more challenging to achieve timing guarantees and functional isolation. One approach to achieving functional isolation is to(More)
—Due to their potential to deliver increased performance over single-core processors, multi-core processors have become mainstream in processor design. Computation-intensive real-time systems must exploit intra-task parallelism to take full advantage of multi-core processing. However, existing results in real-time scheduling of parallel tasks focus on(More)
Based on in vitro data, the U.S. Food and Drug Administration recommends chemical disinfection of raw sprout seeds to reduce enteric pathogens contaminating the seed coats. However, little is known about the effectiveness of decontamination at preventing human disease. In 1999, an outbreak of Salmonella enterica serotype Mbandaka occurred in Oregon,(More)
CONTEXT The Food and Drug Administration Modernization Act of 1997 (FDAMA) and the FDA Amendment Act of 2007 (FDAAA), respectively, established mandates for registration of interventional human research studies on the website clinicaltrials.gov (CTG) and for posting of results of completed studies. OBJECTIVE To characterise, contrast and explain rates of(More)
OBJECTIVE To determine whether training traditional birth attendants to manage several common perinatal conditions could reduce neonatal mortality in the setting of a resource poor country with limited access to healthcare. DESIGN Prospective, cluster randomised and controlled effectiveness study. SETTING Lufwanyama, an agrarian, poorly developed(More)
Effective antiretroviral therapy (ART) requires excellent adherence. Little is known about how to improve ART adherence in many HIV/AIDS-affected countries, including China. We therefore assessed an adherence intervention among HIV-positive patients in southwestern China. Eighty subjects were enrolled and monitored for 6 months. Sixty-eight remaining(More)
Millions of children still die unnecessarily from pneumonia and diarrhoea, mainly in resource-poor settings. A series of collaborative consultations and workshops involving several hundred academic, public health, governmental and private sector stakeholders were convened to identify the key barriers to progress and to issue recommendations. Bottlenecks(More)
BACKGROUND Achieving transparency in clinical trials, through either publishing results in a journal or posting results to the ClinicalTrials.gov (CTG) web site, is an essential public health good. However, it remains unknown what proportion of completed studies achieve public disclosure of results (PDOR), or what factors explain these differences. (More)