Salmonella enterica serovar Typhimurium (Salmonella) is one of the most significant food-borne pathogens affecting both humans and agriculture. We have determined that Salmonella encodes an uptake and utilization pathway specific for a novel nutrient, fructose-asparagine (F-Asn), which is essential for Salmonella fitness in the inflamed intestine (modeled… (More)
Scientific user facilities provide physical resources and technical support that enable scientists to conduct experiments or simulations pertinent to their respective research. One metric for evaluating the scientific value or impact of a facility is the number of publications by users as a direct result of using that facility. Unfortunately, for a variety… (More)
We describe a data-driven unsupervised machine learning approach to extract geo-temporal co-occurrence patterns of asthma and the flu from large-scale electronic healthcare reimbursement claims (eHRC) datasets. Specifically, we examine the eHRC data from 2009 to 2010 pandemic H1N1 influenza season and analyze whether different geographic regions within the… (More)
Insertions in the Salmonella enterica fra locus, which encodes the fructose-asparagine (F-Asn) utilization pathway, are highly attenuated in mouse models of inflammation (>1000-fold competitive index). Here, we report that F-Asn is bacteriostatic to a fraB mutant (IC50 19 μM), but not to the wild-type or a fra island deletion mutant. We hypothesized that… (More)
In spite of social media's lack of structural integrity, accuracy, and reduced noise with respect to other forms of communication, it plays an increasingly vital role in the observation of societal actions before, during, and after significant events. In October 2012, Hurricane Sandy making landfall on the northeastern coasts of the United States… (More)
The recent explosive growth of smart phones and social media creates a unique opportunity to view events from various unique perspectives. Unfortunately, this relatively new form of communication lacks the structural integrity, accuracy, and reduced noise of other forms of communication. Nevertheless, social media increasingly plays a vita role in the… (More)
Scientific user facilities provide resources and support that enable scientists to conduct experiments or simulations pertinent to their respective research. Consequently, it is critical to have an informed understanding of the impact and contributions that these facilities have on scientific discoveries. Leveraging insight into scientific publications that… (More)
We describe a further case of ganglion of the vertebral joint at L4/L5. We give a review of literature about ganglions (synovial cysts) of the vertebral joint and discuss their etiology and their localisation.