Christopher G R Perry

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Repeated transient mRNA bursts precede increases in transcriptional and mitochondrial proteins during training in human skeletal muscle.

Christopher G R Perry, James Lally, Graham P Holloway, George J. F. Heigenhauser, Arend Bonen, Lawrence Leon Spriet
The Journal of physiology
2010

Exercise training induces mitochondrial biogenesis, but the time course of molecular sequelae that accompany repetitive training stimuli remains to be determined in human skeletal muscle. Therefore,… (More)

High-intensity aerobic interval training increases fat and carbohydrate metabolic capacities in human skeletal muscle.

Christopher G R Perry, George J. F. Heigenhauser, Arend Bonen, Lawrence Leon Spriet
Applied physiology, nutrition, and metabolism…
2008

High-intensity aerobic interval training (HIIT) is a compromise between time-consuming moderate-intensity training and sprint-interval training requiring all-out efforts. However, there are few data… (More)

The effects of training in hyperoxia vs. normoxia on skeletal muscle enzyme activities and exercise performance.

Christopher G R Perry, Jason L Talanian, George J. F. Heigenhauser, Lawrence Leon Spriet
Journal of applied physiology
2007

Inspiring a hyperoxic (H) gas permits subjects to exercise at higher power outputs while training, but there is controversy as to whether this improves skeletal muscle oxidative capacity, maximal… (More)

High-intensity interval training increases SIRT1 activity in human skeletal muscle.

Brendon J. Gurd, Christopher G R Perry, George J. F. Heigenhauser, Lawrence Leon Spriet, Arend Bonen
Applied physiology, nutrition, and metabolism…
2010

The effects of training on silent mating-type information regulator 2 homolog 1 (SIRT1) activity and protein in relationship to peroxisome proliferator-activated receptor gamma coactivator-1alpha… (More)

Methods for Assessing Mitochondrial Function in Diabetes

Christopher G R Perry, Daniel A. Kane, Ian R. Lanza, P. Darrell Neufer
Diabetes
2013

A growing body of research is investigating the potential contribution of mitochondrial function to the etiology of type 2 diabetes. Numerous in vitro, in situ, and in vivo methodologies are… (More)

Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1.

Brennan K. Smith, Rebecca J. Ford, +11 authors Gregory R Steinberg
Diabetes
2016

Salsalate is a prodrug of salicylate that lowers blood glucose in patients with type 2 diabetes (T2D) and reduces nonalcoholic fatty liver disease (NAFLD) in animal models; however, the mechanism… (More)

Modelling in vivo creatine/phosphocreatine in vitro reveals divergent adaptations in human muscle mitochondrial respiratory control by ADP after acute and chronic exercise.

Mia Ydfors, Meghan C. Hughes, Robert Laham, Uwe Schlattner, Jessica Norrbom, Christopher G R Perry
The Journal of physiology
2016

KEY POINTS Mitochondrial respiratory sensitivity to ADP is thought to influence muscle fitness and is partly regulated by cytosolic-mitochondrial diffusion of ADP or phosphate shuttling via… (More)

Impairments in mitochondrial palmitoyl-CoA respiratory kinetics that precede development of diabetic cardiomyopathy are prevented by resveratrol in ZDF rats.

Marie-Soleil Beaudoin, Christopher G R Perry, +4 authors Graham P Holloway
The Journal of physiology
2014

Alterations in lipid metabolism within the heart may have a causal role in the establishment of diabetic cardiomyopathy; however, this remains equivocal. Therefore, in the current study we determined… (More)

Over-Expressing Mitofusin-2 in Healthy Mature Mammalian Skeletal Muscle Does Not Alter Mitochondrial Bioenergetics

James S. V. Lally, Eric A. F. Herbst, +4 authors Graham P Holloway
PloS one
2013

The role of mitofusin-2 (MFN-2) in regulating mitochondrial dynamics has been well-characterized in lower order eukaryotic cell lines through the complete ablation of MFN-2 protein. However, to… (More)

Inhibiting myosin-ATPase reveals a dynamic range of mitochondrial respiratory control in skeletal muscle.

Christopher G R Perry, Daniel A. Kane, +8 authors P. Darrell Neufer
The Biochemical journal
2011

Assessment of mitochondrial ADP-stimulated respiratory kinetics in PmFBs (permeabilized fibre bundles) is increasingly used in clinical diagnostic and basic research settings. However, estimates of… (More)

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