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Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein.

• Jean-Yves Talon, Curt M Horvath, +4 authors Adolfo García-Sastre
• Journal of virology
• 2000

We present a novel mechanism by which viruses may inhibit the alpha/beta interferon (IFN-alpha/beta) cascade. The double-stranded RNA (dsRNA) binding protein NS1 of influenza virus is shown to… (More)

A recombinant influenza A virus expressing an RNA-binding-defective NS1 protein induces high levels of beta interferon and is attenuated in mice.

• Nicola R Donelan, Christopher F Basler, Adolfo García-Sastre
• Journal of virology
• 2003

Previously we found that the amino-terminal region of the NS1 protein of influenza A virus plays a key role in preventing the induction of beta interferon (IFN-beta) in virus-infected cells. This… (More)

Newcastle disease virus (NDV)-based assay demonstrates interferon-antagonist activity for the NDV V protein and the Nipah virus V, W, and C proteins.

• Man-seong Park, Megan L Shaw, +6 authors Christopher F Basler
• Journal of virology
• 2003

We have generated a recombinant Newcastle disease virus (NDV) that expresses the green fluorescence protein (GFP) in infected chicken embryo fibroblasts (CEFs). This virus is interferon (IFN)… (More)

Characterization of the reconstructed 1918 Spanish influenza pandemic virus.

• Terrence M. Tumpey, Christopher F Basler, +8 authors Adolfo García-Sastre
• Science
• 2005

The pandemic influenza virus of 1918-1919 killed an estimated 20 to 50 million people worldwide. With the recent availability of the complete 1918 influenza virus coding sequence, we used reverse… (More)

The Ebola virus VP35 protein inhibits activation of interferon regulatory factor 3.

• Christopher F Basler, Andrea Mikulasova, +6 authors Adolfo García-Sastre
• Journal of virology
• 2003

The Ebola virus VP35 protein was previously found to act as an interferon (IFN) antagonist which could complement growth of influenza delNS1 virus, a mutant influenza virus lacking the influenza… (More)

Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling.

• Washington B Cárdenas, Y. H. Loo, +5 authors Christopher F Basler
• Journal of virology
• 2006

The Ebola virus (EBOV) VP35 protein blocks the virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF-3), a transcription factor critical for the induction of alpha/beta… (More)

Ebola virus VP24 proteins inhibit the interaction of NPI-1 subfamily karyopherin alpha proteins with activated STAT1.

• St. Patrick Reid, Charalampos Valmas, Osvaldo Garcia Martinez, Freddy Mauricio Sanchez, Christopher F Basler
• Journal of virology
• 2007

The Zaire ebolavirus protein VP24 was previously demonstrated to inhibit alpha/beta interferon (IFN-alpha/beta)- and IFN-gamma-induced nuclear accumulation of tyrosine-phosphorylated STAT1 (PY-STAT1)… (More)

Pathogenicity of influenza viruses with genes from the 1918 pandemic virus: functional roles of alveolar macrophages and neutrophils in limiting virus replication and mortality in mice.

• Terrence M. Tumpey, Adolfo García-Sastre, +8 authors Christopher F Basler
• Journal of virology
• 2005

The Spanish influenza pandemic of 1918 to 1919 swept the globe and resulted in the deaths of at least 20 million people. The basis of the pulmonary damage and high lethality caused by the 1918 H1N1… (More)

Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35

• Daisy W Leung, Kathleen C. Prins, +9 authors Gaya K Amarasinghe
• Nature Structural &Molecular Biology
• 2010

Ebola viral protein 35 (VP35), encoded by the highly pathogenic Ebola virus, facilitates host immune evasion by antagonizing antiviral signaling pathways, including those initiated by RIG-I–like… (More)

Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus.

• James Stevens, Adam L. Corper, Christopher F Basler, Jeffery K. Taubenberger, P. Palese, Ian A. Wilson
• Science
• 2004

The 1918 "Spanish" influenza pandemic represents the largest recorded outbreak of any infectious disease. The crystal structure of the uncleaved precursor of the major surface antigen of the extinct… (More)

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