Christopher Ede

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3D/2D registration, the automatic assignment of a global rigid-body transformation matching the coordinate systems of patient and preoperative volume scan using projection images, is an important topic in image-guided therapy and radiation oncology. A crucial part of most 3D/2D registration algorithms is the fast computation of digitally rendered(More)
Ever since the development of the first applications in image-guided therapy (IGT), the use of head-mounted displays (HMDs) was considered an important extension of existing IGT technologies. Several approaches to utilizing HMDs and modified medical devices for augmented reality (AR) visualization were implemented. These approaches include video-see through(More)
Synthesis-dependent strand annealing (SDSA) is the preferred mode of homologous recombination in somatic cells leading to an obligatory non-crossover outcome, thus avoiding the potential for chromosomal rearrangements and loss of heterozygosity. Genetic analysis identified the Srs2 helicase as a prime candidate to promote SDSA. Here, we demonstrate that(More)
We present a simple and rapid method for generation of perspective digitally rendered radiographs (DRR) for 2D/3D registration based on splat rendering. Suppression of discretization artefacts by means of computation of Gaussian footprints--which is a considerable computational burden in classical splat rendering--is replaced by stochastic motion of either(More)
Inducible transcription systems play a crucial role in a wide array of synthetic biology circuits. However, the majority of inducible promoters are constructed from a limited set of tried-and-true promoter parts, which are susceptible to common shortcomings such as high basal expression levels (i.e., leakiness). To expand the toolbox for regulated mammalian(More)
This paper describes an experiment and its results concerning research that has been going on for a number of years in the area of anthropomorphic user interface feedback. The main aims of the research have been to examine the effectiveness and user satisfaction of anthropomorphic feedback in various domains. The results are of use to all interactive(More)
Targeted therapies promise to increase the safety and efficacy of treatments against diseases ranging from cancer to viral infections. However, the vast majority of targeted therapeutics relies on the recognition of extracellular biomarkers, which are rarely restricted to diseased cells and are thus prone to severe and sometimes-fatal off-target toxicities.(More)
We discuss the approximation of the meanfield terms appearing in computations of the multi-configuration time-dependent Hartree–Fock method for the solution of the timedependent multi-particle (electronic) Schrödinger equation by hierarchical matrices. We give theoretical error bounds for the cross approximation defined by low rank approximations of(More)
We are developing an optical see through head mounted display in which preoperative planning data provided by a computer aided surgery system is overlaid to the optical image of the patient. In order to cope with head movements of the surgeon the device has to be calibrated for a wide zoom and focus range. For such a calibration accurate and robust(More)
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