Christopher E. Carr

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Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans.

Alexander A. Soukas, Elizabeth A. Kane, Christopher E. Carr, Justine A Melo, Gary Ruvkun
Genes & development
2009

Rictor is a component of the target of rapamycin complex 2 (TORC2). While TORC2 has been implicated in insulin and other growth factor signaling pathways, the key inputs and outputs of this kinase… (More)

C. elegans major fats are stored in vesicles distinct from lysosome-related organelles.

Eyleen J. O'Rourke, Alexander A. Soukas, Christopher E. Carr, Gary Ruvkun
Cell metabolism
2009

Genetic conservation allows ancient features of fat storage endocrine pathways to be explored in C. elegans. Multiple studies have used Nile red or BODIPY-labeled fatty acids to identify regulators… (More)

Gene activities that mediate increased life span of C. elegans insulin-like signaling mutants.

Andrew V Samuelson, Christopher E. Carr, Gary Ruvkun
Genes & development
2007

Genetic and RNA interference (RNAi) screens for life span regulatory genes have revealed that the daf-2 insulin-like signaling pathway plays a major role in Caenorhabditis elegans longevity. This… (More)

Induction of Cytoprotective Pathways Is Central to the Extension of Lifespan Conferred by Multiple Longevity Pathways

David E. Shore, Christopher E. Carr, Gary Ruvkun
PLoS genetics
2012

Many genetic and physiological treatments that extend lifespan also confer resistance to a variety of stressors, suggesting that cytoprotective mechanisms underpin the regulation of longevity. It has… (More)

An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer

Lianfeng Wu, Ben Zhou, +10 authors Alexander A. Soukas
Cell
2016

Metformin has utility in cancer prevention and treatment, though the mechanisms for these effects remain elusive. Through genetic screening in C. elegans, we uncover two metformin response elements:… (More)

The Most Conserved Genome Segments for Life Detection on Earth and Other Planets

Thomas A. Isenbarger, Christopher E. Carr, +5 authors Gary Ruvkun
Origins of Life and Evolution of Biospheres
2008

On Earth, very simple but powerful methods to detect and classify broad taxa of life by the polymerase chain reaction (PCR) are now standard practice. Using DNA primers corresponding to the 16S… (More)

Biochemical and High Throughput Microscopic Assessment of Fat Mass in Caenorhabditis Elegans

Elizabeth C. Pino, Christopher M. Webster, Christopher E. Carr, Alexander A. Soukas
Journal of visualized experiments : JoVE
2013

The nematode C. elegans has emerged as an important model for the study of conserved genetic pathways regulating fat metabolism as it relates to human obesity and its associated pathologies. Several… (More)

The Apollo Number: Space Suits, Self-Support, and the Walk-Run Transition

BACKGROUND How space suits affect the preferred walk-run transition is an open question with relevance to human biomechanics and planetary extravehicular activity. Walking and running energetics… (More)

Space suit bioenergetics: framework and analysis of unsuited and suited activity.

Christopher E. Carr, Dava J. Newman
Aviation, space, and environmental medicine
2007

Metabolic costs limit the duration and intensity of extravehicular activity (EVA), an essential component of future human missions to the Moon and Mars. Energetics Framework: We present a framework… (More)

Advancing the search for extra-terrestrial genomes

Christopher E. Carr, Angel Mojarro, +10 authors Gary Ruvkun
2016 IEEE Aerospace Conference
2016

Widespread synthesis of complex organics, including nucleobases and ribose precursors, occurred early in the history of the solar system in the solar nebula. These organics, delivered to multiple… (More)

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