Learn More
The GGGGCC (G4C2) intronic repeat expansion within C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Intranuclear neuronal RNA foci have been observed in ALS and FTD tissues, suggesting that G4C2 RNA may be toxic. Here, we demonstrate that the expression of 38× and 72× G4C2 repeats form(More)
Recent work by the Encyclopedia of DNA Elements project showed that non-protein-coding RNAs account for an unexpectedly large proportion of the human genome. Among these non-coding RNAs are microRNAs (miRNAs), which are small RNA molecules that modulate protein expression by degrading mRNA or repressing mRNA translation. MiRNAs have been shown to play(More)
Entry of Plasmodium falciparum into human red blood cells is a stressful event for both the host and the parasite. Conversion of hemoglobin into usable food by P. falciparum is accompanied by the production of chemically reactive and toxic molecules called oxidants. Examination of the temporal sequence of gene expression during the intraerythrocytic(More)
  • 1