Christopher E. Kibbey

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Recent progress in the design of new polymer membrane-based potentiometric ion-, gas- and bio-selective electrodes in chemistry laboratories at the University of Michigan (Ann Arbor) is reviewed. Emphasis is placed on describing the performance of devices for measuring anions (e.g., salicylate, thiocyanate, chloride and heparin) and gases (e.g., ammonia,(More)
Automated log P, pK(a), solubility, and chemical stability systems comprise an integrated process that provides early stage physicochemical property data to the discovery research organization. Capillary electrophoresis (CE) techniques are used to experimentally determine pK(a) and log P. Solubility is determined using a quasi-equilibrium approach employing(More)
Several surfactant systems were evaluated based on their system constants determined by the solvation parameter model for the design of a surrogate chromatographic model for the rapid estimation of octanol-water partition coefficient (log Pow) by microemulsion electrokinetic chromatography. The system constant ratios responsible for the log Pow partition(More)
The reversed-phase chromatographic behavior of planar and non-planar polycyclic aromatic hydrocarbons (PAHs) is investigated on tetraphenylporphyrin and two metallotetraphenylporphyrin [Sn(IV), In(III)] bonded stationary phases using methanol-water and acetonitrile-water as mixed solvent mobile phases. Large differences in the capacity factors of aromatic(More)
A tetraphenylporphyrin-based stationary phase for high-performance liquid chromatography is prepared by attaching a p-carboxyphenyl derivative of the porphyrin to aminopropyl silica gel through an amide bond. This stationary-phase support is used for the reversed-phase separation of several polycyclic aromatic hydrocarbons and is shown to exhibit novel(More)
Practicing medicinal chemists tend to treat a lead compound as an assemblage of its substructural parts. By iteratively confining their synthetic efforts in a localized fashion, they are able to systematically investigate how minor changes in certain portions of the molecule effect the properties of interest in the logical expectation that the observed(More)
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