Christopher E. Kibbey

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Several surfactant systems were evaluated based on their system constants determined by the solvation parameter model for the design of a surrogate chromatographic model for the rapid estimation of octanol-water partition coefficient (log Pow) by microemulsion electrokinetic chromatography. The system constant ratios responsible for the log Pow partition(More)
Automated log P, pK(a), solubility, and chemical stability systems comprise an integrated process that provides early stage physicochemical property data to the discovery research organization. Capillary electrophoresis (CE) techniques are used to experimentally determine pK(a) and log P. Solubility is determined using a quasi-equilibrium approach employing(More)
Recent progress in the design of new polymer membrane-based potentiometric ion-, gas- and bio-selective electrodes in chemistry laboratories at the University of Michigan (Ann Arbor) is reviewed. Emphasis is placed on describing the performance of devices for measuring anions (e.g., salicylate, thiocyanate, chloride and heparin) and gases (e.g., ammonia,(More)
The advantages of evaporative light-scattering detection over UV detection for the quantitation of combinatorial libraries composed of small organic compounds by HPLC are described. The detector's response is independent of the sample chromophore, which makes it well-suited to chromatographie analyses of mixtures of dissimilar solutes. Thus, HPLC with(More)
A tetraphenylporphyrin-based stationary phase for high-performance liquid chromatography is prepared by attaching a p-carboxyphenyl derivative of the porphyrin to aminopropyl silica gel through an amide bond. This stationary-phase support is used for the reversed-phase separation of several polycyclic aromatic hydrocarbons and is shown to exhibit novel(More)
The reversed-phase chromatographic behavior of planar and non-planar polycyclic aromatic hydrocarbons (PAHs) is investigated on tetraphenylporphyrin and two metallotetraphenylporphyrin [Sn(IV), In(III)] bonded stationary phases using methanol-water and acetonitrile-water as mixed solvent mobile phases. Large differences in the capacity factors of aromatic(More)
Practicing medicinal chemists tend to treat a lead compound as an assemblage of its substructural parts. By iteratively confining their synthetic efforts in a localized fashion, they are able to systematically investigate how minor changes in certain portions of the molecule effect the properties of interest in the logical expectation that the observed(More)
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