Christopher Domush

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We investigated the effects of the sensory neuropeptide substance P (SP) on amylase and fluid secretion in the isolated vascularly perfused rat pancreas. SP inhibited CCK-induced amylase release and secretin-induced juice flow via the pancreatic duct in a dose-related fashion. Threshold inhibition occurred following addition of 10(-10) M SP to the(More)
Kirkwood, Kimberly S., Edward H. Kim, Xiao Dong He, Edna Q. Calaustro, Christopher Domush, Shandra K. Yoshimi, Eileen F. Grady, John Maa, Nigel W. Bunnett, and Haile T. Debas. Substance P inhibits pancreatic exocrine secretion via a neural mechanism. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G314–G320, 1999.—We investigated the effects of the(More)
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