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  • Kristian Kaufmann, Ian M. Romaine, +14 authors Christopher David Weaver
  • Medicine, Chemistry
  • ACS chemical neuroscience
  • 2013 (First Publication: 18 September 2013)
  • The G-protein activated, inward-rectifying potassium (K(+)) channels, "GIRKs", are a family of ion channels (Kir3.1-Kir3.4) that has been the focus of intense research interest for nearly twoContinue Reading
  • Alice L. Rodriguez, Mark D. Grier, +17 authors P Jeffrey Conn
  • Medicine, Biology
  • Molecular pharmacology
  • 2010 (First Publication: 1 December 2010)
  • Modulators of metabotropic glutamate receptor subtype 5 (mGluR5) may provide novel treatments for multiple central nervous system (CNS) disorders, including anxiety and schizophrenia. AlthoughContinue Reading
  • L. Michelle Lewis, Gautam Bhave, +7 authors Jerod S Denton
  • Medicine, Chemistry
  • Molecular pharmacology
  • 2009 (First Publication: 1 November 2009)
  • The renal outer medullary potassium channel (ROMK) is expressed in the kidney tubule and critically regulates sodium and potassium balance. The physiological functions of other inward rectifying K(+)Continue Reading
  • Christopher David Weaver, Douglas J. Sheffler, +14 authors Craig W Lindsley
  • Chemistry, Medicine
  • Current topics in medicinal chemistry
  • 2009 (First Publication: 1 September 2009)
  • This article describes the discovery and development of the first highly selective, small molecule antagonist of the muscarinic acetylcholine receptor subtype I (mAChR1 or M(1)). An M(1) functional,Continue Reading