Christopher D. Salthouse

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Subthreshold filters offer the low power and wide tunable range required for use in fully implantable bionic ears. The major design challenge that must be met is increasing the linear range. A capacitive-attenuation technique is presented and refined to allow the construction of wide-linear-range bandpass filters with greater than 1 pp swings. For a 100–200(More)
We report a programmable analog bionic ear (cochlear implant) processor in a 1.5-microm BiCMOS technology with a power consumption of 211 microW and 77-dB dynamic range of operation. The 9.58 mm x 9.23 mm processor chip runs on a 2.8 V supply and has a power consumption that is lower than state-of-the-art analog-to-digital (A/D)-then-DSP designs by a factor(More)
Continuous, real-time tracking of eye gaze is valuable in a variety of scenarios including hands-free interaction with the physical world, detection of unsafe behaviors, leveraging visual context for advertising, life logging, and others. While eye tracking is commonly used in clinical trials and user studies, it has not bridged the gap to everyday consumer(More)
We describe a 470pW 16-channel analog VLSI processor for bionic ears (cochlear implants) and portable speechrecognition front ends. The power consumption of the processor is kept at low levels through the use of subthreshold CMOS technology. Each channel is composed of a programmable bandpass filter, an envelope detector, and a logarithmic dual-slope(More)
The human eye offers a fascinating window into an individual's health, cognitive attention, and decision making, but we lack the ability to continually measure these parameters in the natural environment. The challenges lie in: a) handling the complexity of continuous high-rate sensing from a camera and processing the image stream to estimate eye(More)
This paper demonstrates the use of software radio techniques in the context of sensing, rather than communications. It describes code-division multiplexing (CDMA) and time-division multiplexing (TDMA) of a receiver channel in an electric field sensing system. The only hardware used is a front-end gain stage consisting of two opamps and a microcontroller.(More)
Zebrafish are a useful vertebrate model for the study of development, behavior, disease and cancer. A major advantage of zebrafish is that large numbers of animals can be economically used for experimentation; however, high-throughput methods for imaging live adult zebrafish had not been developed. Here, we describe protocols for building a light-emitting(More)
Epigenetic gene regulation is a dynamic process orchestrated by chromatin-modifying enzymes. Many of these master regulators exert their function through covalent modification of DNA and histone proteins. Aberrant epigenetic processes have been implicated in the pathophysiology of multiple human diseases. Small-molecule inhibitors have been essential to(More)
Proteases play important roles in a variety of pathologies from heart disease to cancer. Quantitative measurement of protease activity is possible using a novel spectrally matched dual fluorophore probe and a small animal lifetime imager. The recorded fluorescence from an activatable fluorophore, one that changes its fluorescent amplitude after biological(More)