Christopher Cyril Sullivan

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OBJECTIVES The aim of this research was to test whether constitutive expression of hypoxia-inducible factor 1-alpha (HIF-1alpha) influences infarction size and cardiac performance after myocardial infarction. BACKGROUND A major question in clinical medicine is whether infarction size and border zone remodeling of the heart can be influenced by the(More)
BACKGROUND Biochemical, genetic, and clinical evidence indicates that smooth-muscle proliferation around small pulmonary vessels is an essential part of the pathogenesis of pulmonary hypertension. Mutations in the bone morphogenetic protein receptor type 2 (BMPR2) have been linked to familial cases of pulmonary hypertension, but the molecular basis of the(More)
Smooth muscle cell proliferation around small pulmonary vessels is essential to the pathogenesis of pulmonary hypertension. Here we describe a molecular mechanism and animal model for this vascular pathology. Rodents engineered to express angiopoietin 1 (Ang-1) constitutively in the lung develop severe pulmonary hypertension. These animals manifest diffuse(More)
BACKGROUND Angiopoietin-1 gene expression in human pulmonary hypertensive lungs is directly proportional to increasing pulmonary vascular resistance. We hypothesized that targeted overexpresssion of angiopoietin-1 in the lung would cause persistent pulmonary hypertension in an animal model. METHODS We injected 2 x 10(10) genomic particles of(More)
OBJECTIVE Recent gene therapy strategies have relied on the use of adenovirus or plasmid as vehicles for gene delivery to the heart. These approaches have been limited by low transduction frequencies and transient transgene expression. We sought to determine whether adeno-associated virus produces more stable, higher efficiency gene expression in the rodent(More)
OBJECTIVES Overexpression of angiopoietin 1 in the lung has been associated with human pulmonary hypertension. We hypothesized that inhibiting angiopoietin 1 signaling in the lung by administration of a receptor antagonist would block the development of pulmonary hypertensive vasculopathy in rodent models. METHODS We injected 2 and 4 x 10(10) genomic(More)
There are a large number of cardiovascular diseases that could be treated by myocardial gene transfer. These include congestive heart failure, ischemic heart disease, and cardiomyopathy. In addition to its potential for treatment of disease, myocardial gene transfer is useful for the analysis of gene expression and promoter function and for generating(More)
An analysis of the current Northrop helicopter obstacle avoidance system (OASYS) prototype with a fixed forward mounting, 25 x 50 degree field of view, 860 nanometer wavelength LADAR, was conducted to determine system effectiveness during simulated aircraft level accelerations ranging from 0 to 100 knots, and at acceleration rates of from 0 to 2.9(More)
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