Christopher C. West

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Mesenchymal stem/stromal cells (MSCs) are adult multipotent progenitors of great promise for cell therapy. MSCs can mediate tissue regeneration, immunomodulation, and hematopoiesis support. Despite the unique properties of MSCs and their broad range of potential clinical applications, the very nature of these cells has been uncertain. Furthermore, MSCs are(More)
Mesenchymal stem/stromal cells (MSCs) can regenerate tissues by direct differentiation or indirectly by stimulating angiogenesis, limiting inflammation, and recruiting tissue-specific progenitor cells. MSCs emerge and multiply in long-term cultures of total cells from the bone marrow or multiple other organs. Such a derivation in vitro is simple and(More)
Despite progress in modelling human drug toxicity, many compounds fail during clinical trials due to unpredicted side effects. The cost of clinical studies are substantial, therefore it is essential that more predictive toxicology screens are developed and deployed early on in drug development (Greenhough et al 2010). Human hepatocytes represent the current(More)
Adipose tissue is an attractive source of mesenchymal stem cells (MSC) as it is largely dispensable and readily accessible through minimally invasive procedures such as liposuction. Until recently MSC could only be isolated in a process involving ex-vivo culture and their in-vivo identity, location and frequency remained elusive. We have documented that(More)
blades, I/O expansion adapters, and units J. E. Hughes M. L. Scollard R. Land J. Parsonese C. C. West V. A. Stankevich C. L. Purrington D. Q. Hoang G. R. Shippy M. L. Loeb M. W. Williams B. A. Smith D. M. Desai This paper describes the electrical architecture and design of the IBM eServere BladeCentert processor blades, expansion blades, and input/output(More)
To facilitate metabolomics analysis of stem cell differentiation, Alakpa et al. designed supramolecular hydrogels with tunable stiffness but simple chemical functionality. These gels facilitate stiffness-tuned stem cell differentiation without having to rely on biochemical functionalization. They could be used for surveying the usage of biological small(More)
Atrophic non-union is attributed to biological failure of the fracture repair process. It occurs in up to 10% of fractures, results in significant morbidity to patients, and treatment often requires complex reconstructive procedures. We tested the ability of human bone derived marrow mesenchymal stem cells (MSC), and human adipose derived pericytes (the(More)
CONTEXT Levels of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1), which regenerates active glucocorticoids, are selectively elevated in adipose tissue in human obesity and metabolic syndrome, both conditions associated with chronic low-grade inflammation. 11β-HSD1 expression is induced by proinflammatory cytokines in a variety of cell types, including(More)
Tattooing is a common form of decorative body modification that has been practised since ancient times and which remains popular worldwide. Common complications include infections, granulomas, allergic disorders and other skin diseases. There are also reports of cutaneous malignancies arising from tattoos including basal cell carcinoma, squamous cell(More)