Christopher C. Ledford

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The present study tested the hypothesis that separate neural substrates mediate cocaine relapse elicited by drug-associated contextual stimuli vs explicit conditioned stimuli (CSs) and cocaine. Specifically, we investigated the involvement of the dorsal hippocampus (DH), basolateral amygdala (BLA), and dorsomedial prefrontal cortex (dmPFC) in contextual(More)
Evidence has extensively implicated the amygdala in the associative learning process for appetitive reinforcers. Recent interest has focused on the role of the amygdala in the learned associations that occur during the process of drug addiction and relapse. Using an animal model of relapse after chronic cocaine self-administration, we found that rats(More)
A 22-year-old woman with no significant medical history developed acute left shoulder pain and severe restrictions in range of motion after a seasonal influenza vaccine injection. Imaging by MRI, approximately 8 weeks after the injection, and by ultrasound, approximately 9.5 weeks after the injection demonstrated contusions on the humerus, injury of the(More)
Reinstatement of extinguished drug-seeking behavior following chronic drug self-administration has been demonstrated in rats in the presence of conditioned cues. This experimental model of cue-induced relapse can be used to assess the neural circuitry involved in relapse. We have previously shown that blockade of dopamine D1 receptors in the basolateral(More)
OBJECTIVE Despite evidence-based recommendations, physical activity as a self-management technique is underutilized. Many physical activity interventions require significant resources, ranging from repeated phone follow-up with nursing staff to intensive sessions with cooperating physical therapists. This intervention, Extending Physician ReACH(More)
Rationale: Reinstatement of extinguished drag-seeking behavior following chronic drag selfadministration has been demonstrated in rats in the presence of conditioned cues. We have previously shown that blockade of dopamine (DA) Dl receptors in the basolateral amygdala (BLA) abolishes conditioned cue-induced reinstatement of cocaine-seeking behavior.(More)
OBJECTIVE This study explored patient recall of clinician presentation of information about prescription medication, looking specifically for communication patterns and differences by patient individual characteristics and by medication availability type. METHODS A cross sectional survey collected information about 216 patients' perceptions of clinician(More)
OBJECTIVE To further conceptualize and operationalize patient activation (PA), using measures from patient, physician, and researcher perspectives. DATA SOURCE/STUDY SETTING Multimethod observation in 2010 within a family medicine clinic. STUDY DESIGN Part of an intervention with 130 patients with type 2 diabetes, this observational study further looked(More)
BACKGROUND Clinician counseling about medication can improve patient understanding and adherence. This study developed a teaching session for physician learners about medication prescribing and communication, with evaluation at the physician and patient levels. OBJECTIVE We analyzed whether patients would perceive and report more comprehensive clinician(More)
Evidence-Based Answer Proactive support in many forms, provided by health care professionals or laypersons, increases the duration of any breastfeeding (including partial and exclusive) and exclusive breastfeeding. Face-to-face support is superior to telephonebased interventions. Support for continued breastfeeding is more effective in areas where baseline(More)