Christopher Bladen

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Molecular basis of protein kinase C-induced activation of ATP-sensitive potassium channels.

Peter E. Light, Christopher Bladen, Robert J. Winkfein, M. P. Walsh, Robert J. French
Proceedings of the National Academy of Sciences…
2000

Potassium channels that are inhibited by internal ATP (K(ATP) channels) provide a critical link between metabolism and cellular excitability. Protein kinase C (PKC) acts on K(ATP) channels to… (More)

Effects of Cav3.2 channel mutations linked to idiopathic generalized epilepsy.

Houman Khosravani, Christopher Bladen, David B. Parker, Terrance P. Snutch, John E. McRory, Gerald W Zamponi
Annals of neurology
2005

Heron and colleagues (Ann Neurol 2004;55:595-596) identified three missense mutations in the Cav3.2 T-type calcium channel gene (CACNA1H) in patients with idiopathic generalized epilepsy. None of the… (More)

A large, voltage-dependent channel, isolated from mitochondria by water-free chloroform extraction.

Evgeny V. Pavlov, Eleonora Zakharian, +4 authors Robert J. French
Biophysical journal
2005

We examined ion channels derived from a chloroform extract of isolated, dehydrated rat liver mitochondria. The extraction method was previously used to isolate a channel-forming complex containing… (More)

Molecular characterization of a type II cyclic GMP-dependent protein kinase expressed in the rat brain.

A el-D El-Husseini, Christopher Bladen, Steven R. Vincent
Journal of neurochemistry
1995

We applied reverse transcription-PCR to examine the gene expression of cyclic GMP (cGMP)-dependent protein kinase in the rat brain. A PCR product with the size predicted from the type II… (More)

Autoradiographic localization of [3H]-cyclic GMP binding sites in the rat brain.

Christopher Bladen, D F Loewen, Steven R. Vincent
Journal of chemical neuroanatomy
1996

Both the atriopeptides and nitric oxide act in the nervous system by activating guanylyl cyclases to stimulate the production of cyclic GMP. Thus a key to understanding the roles of these messengers… (More)

The pore, not cytoplasmic domains, underlies inactivation in a prokaryotic sodium channel.

Evgeny V. Pavlov, Christopher Bladen, Robert K Winkfein, Catherine Teimei Diao, Perry Dhaliwal, Robert J. French
Biophysical journal
2005

Kinetics and voltage dependence of inactivation of a prokaryotic voltage-gated sodium channel (NaChBac) were investigated in an effort to understand its molecular mechanism. NaChBac inactivation… (More)

Low-affinity binding sites for 1,4-dihydropyridines in skeletal muscle transverse tubule membranes revealed by changes in the fluorescence of felodipine.

The fluorescence changes accompanying the binding of the fluorescent calcium channel antagonist, felodipine, to transverse tubule membranes from rabbit skeletal muscle have been used to characterize… (More)

Characterization and localization of [3H] cyclosporin A binding sites in rat brain.

The immunosuppressant drug [3H]cyclosporin A binds specifically and with high affinity to rat brain membrane preparations. The highest density of binding sites was observed in the hippocampus,… (More)

Hypertension and the Department of Health and Human Services.

Hypertension affects from 17% to 25% of all Americans. Because of its fundamental charge to help protect the public health, the Department of Health and Human Services (HHS) is substantially… (More)

Kinetics of binding of dihydropyridine calcium channel ligands to skeletal muscle membranes: evidence for low-affinity sites and for the involvement of G proteins.

Detailed kinetic studies of the binding of the calcium channel antagonist (+)-[3H]PN200-110 to membrane preparations from rabbit skeletal muscle have demonstrated that, in addition to the… (More)

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