Learn More
Male rats were thermally dehydrated by exposure without water to an environmental temperature of 40 degrees C for 0-4 hr or to environmental temperatures of 25-40 degrees C for 4 hr. Water intake was then measured for 2 hr or a blood sample was taken to determine the effect of heat exposure on body water status. Evaporative water loss and water intake(More)
Temporal variation in spontaneous water intake in rats is well established but little is known about temporal variation in water intake following dehydration. In the present study different male Sprague-Dawley strain rats were exposed without water for 3 h to either a 25 degrees C or a 40 degrees C environment every 4 h for 20 h. The rats were then allowed(More)
IL-2 potentiates both growth and cytotoxic function of T lymphocytes and NK cells. Resting peripheral blood NK cells can respond directly to rIL-2, without requirement for accessory cells or cofactors, and enhanced cytotoxicity can be measured within a few hours after exposure to this lymphokine. In this study, we describe an activation antigen, Leu-23,(More)
Female rats administered serotonin (0.25 to 4.0 mg/kg, s.c.) showed a dose-dependent increase in water intake. The dipsogenic response was nearly maximal when 2 mg/lg was administered s.c. and plateaued by 2 hr after treatment. l-5-Hydroxytryptophan (5-HTP), the precursor of serotonin, is also a potent dipsogen which induces drinking by way of the(More)
A technique is presented for preparing a durable thermode implant in the hypothalamus of the rhesus monkey. In unanesthetized monkeys implanted with thermodes in the anterior hypothalamic area of the brain, a linear relation was found between local sweat rates on the general body surface and clamped hypothalamic temperature. Changes in skin temperature were(More)
The effects of dipsogenic doses of l-5-hydroxytryptophan (5-HTP) and serotonin on plasma renin activity (PRA), blood pressure, and body temperature were determined in unanesthetized female rats. Both serotonin (2 mg/kg, s.c.) and 5-HTP (25 mg/kg, s.c.) induced six-fold increases in PRA measured 1 hr after drug administration. The central and peripheral(More)
The relative contribution of cellular and extracellular water deficits to the genesis of thirst due to thermal dehydration was studied in male Sprague-Dawley rats following exposure to a 40 degrees C environment for 4 h. Intragastric (I.G.) and intravenous (I.V.) preloads of water reduced the elevated plasma sodium and plasma osmolality of thermally(More)
Studies were undertaken to evaluate the role of central noradrenergic neurons in the tail skin temperature (TST) surge that accompanies morphine withdrawal in the rat. A 5 degrees C increase in TST and a 1-2 degrees C decrease in rectal temperature (Tr) was observed following administration of a dose of naloxone HCl (NAL, 1 mg/kg, s.c.) which precipitated(More)