Christopher Allan Hamm

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Genetic sampling of endangered species can inform conservation management and potentially aid the long-term survival of a species. However, when dealing with very small populations of rare species, the sacrifice of whole animals may not be desirable or permitted. We set out to develop a demonstrably non-lethal method of obtaining DNA from the(More)
The aim of this study is to search for new therapeutic targets for atypical teratoid–rhabdoid tumors (ATRT). To achieve this, we compared the expression of 365 microRNAs among ATRT, medulloblastomas, and normal brain. MiR-221 and miR-222 were within the top differentially expressed microRNAs. The deregulated expression of miR221/222 was demonstrated to(More)
Abnormal patterns of DNA methylation are observed in several types of human cancer. While localized DNA methylation of CpG islands has been associated with gene silencing, the effect that genome-wide loss of methylation has on tumorigenesis is not completely known. To examine its effect on tumorigenesis, we induced DNA demethylation in a rat model of human(More)
The future of drug design and the development of new therapeutics will rely on our ability to unravel the complexities of the epigenome in normal and disease states. Proper epigenetic regulation is essential for normal differentiation in embryogenesis and development. Conversely, abnormal epigenetic regulation is a feature of complex diseases, including(More)
Herbivorous insects represent one of the most successful animal radiations known. They occupy a wide range of niches, feed on a great variety of plants, and are species rich; yet the factors that influence their diversification are poorly understood. Host breadth is often cited as a major factor influencing diversification, and, according to the Oscillation(More)
Conservation of at-risk species requires multi-faceted and carefully-considered management approaches to be successful. For arthropods, the presence of endosymbiotic bacteria, such as Wolbachia (Rickettsiales: Rickettsiaceae), may complicate management plans and exacerbate the challenges faced by conservation managers. Wolbachia poses a substantial and(More)
Chondrosarcomas are malignant cartilage tumors that do not respond to traditional chemotherapy or radiation. The 5-year survival rate of histologic grade III chondrosarcoma is less than 30%. An animal model of chondrosarcoma has been established - namely, the Swarm Rat Chondrosarcoma (SRC) - and shown to resemble the human disease. Previous studies with(More)
Epigenetics is a molecular phenomenon that pertains to heritable changes in gene expression that do not involve changes in the DNA sequence. Epigenetic modifications in a whole genome, known as the epigenome, play an essential role in the regulation of gene expression in both normal development and disease. Traditional epigenetic changes include DNA(More)
Prairie fen is a globally rare, groundwater dependent peatland community restricted to discrete portions of the glaciated north central USA. Prairie fen harbours a diverse flora composed of sedge wetland and tallgrass prairie species, which in turn support a diversity of rare insects. In Michigan, USA over 20% of the state’s insects of conservation concern(More)
I isolated and characterized 8 polymorphic anonymous nuclear loci from the federally endangered Mitchell’s satyr butterfly, Neonympha mitchellii mitchellii (Lepidoptera: Nymphalidae). All loci reported here are polymorphic and will serve as important tools in the conservation of this rare butterfly.