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Warm-Sensitive Neurons that Control Body Temperature
Thermoregulation is one of the most vital functions of the brain, but how temperature information is converted into homeostatic responses remains unknown. Here, we use an unbiased approach forExpand
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Thirst neurons anticipate the homeostatic consequences of eating and drinking
Thirst motivates animals to drink in order to maintain fluid balance. Thirst has conventionally been viewed as a homeostatic response to changes in blood volume or tonicity. However, most drinkingExpand
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Neural circuits underlying thirst and fluid homeostasis
Thirst motivates animals to find and consume water. More than 40 years ago, a set of interconnected brain structures known as the lamina terminalis was shown to govern thirst. However, owing to theExpand
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Hunger neurons drive feeding through a sustained, positive reinforcement signal
The neural mechanisms underlying hunger are poorly understood. AgRP neurons are activated by energy deficit and promote voracious food consumption, suggesting these cells may supply the fundamentalExpand
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The Forebrain Thirst Circuit Drives Drinking through Negative Reinforcement
The brain transforms the need for water into the desire to drink, but how this transformation is performed remains unknown. Here we describe the motivational mechanism by which the forebrain thirstExpand
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A gut-to-brain signal of fluid osmolarity controls thirst satiation
Satiation is the process by which eating and drinking reduce appetite. For thirst, oropharyngeal cues have a critical role in driving satiation by reporting to the brain the volume of fluid that hasExpand
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The neural basis of thirst
Author(s): Zimmerman, Christopher A | Advisor(s): Knight, Zachary A | Abstract: The physiological conditions within our bodies are remarkably stable. To maintain this internal stability (calledExpand
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The origins of thirst
Sensory signals arise throughout the body and converge in the brain to regulate drinking We experience thirst every day, but where does this sensation come from? In the 1950s, Bengt AnderssonExpand
Layers of signals that regulate appetite
All meals come to an end. This is because eating and drinking generate feedback signals that communicate to the brain what and how much has been consumed. Here we review our current understanding ofExpand