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The relationship between immunodominance, DM editing, and the kinetic stability of MHC class II:peptide complexes
Summary:  Immunodominance refers to the restricted antigen specificity of T cells detected in the immune response after immunization with complex antigens. Despite the presence of many potentialExpand
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The kinetic stability of MHC class II:peptide complexes is a key parameter that dictates immunodominance.
T cell priming to exogenous antigens reflects regulated antigen processing in dendritic cells, subsequent homing to lymph nodes, sustained interactions between T cells and antigen-bearing dendriticExpand
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The impact of DM on MHC class II–restricted antigen presentation can be altered by manipulation of MHC–peptide kinetic stability
DM edits the peptide repertoire presented by major histocompatibility complex class II molecules by professional antigen-presenting cells (APCs), favoring presentation of some peptides over others.Expand
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Direct Ex Vivo Analyses of HLA-DR1 Transgenic Mice Reveal an Exceptionally Broad Pattern of Immunodominance in the Primary HLA-DR1-Restricted CD4 T-Cell Response to Influenza Virus Hemagglutinin
ABSTRACT The recent threat of an avian influenza pandemic has generated significant interest in enhancing our understanding of the events that dictate protective immunity to influenza and inExpand
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A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy
It is assumed that anti-CTLA-4 antibodies cause tumor rejection by blocking negative signaling from B7-CTLA-4 interactions. Surprisingly, at concentrations considerably higher than plasma levelsExpand
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Immunodominance of CD4 T Cells to Foreign Antigens Is Peptide Intrinsic and Independent of Molecular Context: Implications for Vaccine Design1
Immunodominance refers to the restricted peptide specificity of T cells that are detectable after an adaptive immune response. For CD4 T cells, many of the mechanisms used to explain this selectivityExpand
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Immunodominance in CD4 T-cell responses: implications for immune responses to influenza virus and for vaccine design
CD4 T cells play a primary role in regulating immune responses to pathogenic organisms and to vaccines. Antigen-specific CD4 T cells provide cognate help to B cells, a requisite event forExpand
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IL-4 Attenuates Th1-Associated Chemokine Expression and Th1 Trafficking to Inflamed Tissues and Limits Pathogen Clearance
Interleukin 4 (IL-4) plays a central role in the orchestration of Type 2 immunity. During T cell activation in the lymph node, IL-4 promotes Th2 differentiation and inhibits Th1 generation. In theExpand
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Regulating Treg cells at sites of inflammation.
Regulatory T (Treg) cells are emerging as common components in the development of immunity to both self and foreign antigen. With their ubiquitous participation comes the need to regulate theExpand
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Vladimir Vysotsky and His Cult
ime usually calms human emotions, helps in acquiring distance, and leads to a more balanced judgment of any event, phenomenon, or person. So far this traditional wisdom does not seem to hold trueExpand
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