Christopher A Derderian

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The human CCND1/PRAD1 gene, located in the 11q13 chromosomal region, encodes a cyclin D protein with potential oncogenic capacity and is involved in several human malignancies. The amplification and expression status of CCND1 was investigated in a series of oesophageal tumours. CCND1 is amplified in 54% and overexpressed in 63% of the tumours of the(More)
PURPOSE Posterior vault expansion using distraction osteogenesis has become a vital instrument in our institution, particularly as a first-line treatment in syndromic craniosynostosis. In this review, we highlight the several advantages, diverse utility, and technicalities of the operative procedure. METHODS A review of the literature and explanation of(More)
PURPOSE: Neurocognitive studies in school-age children with craniosynostosis reveal lower scores compared to controls. Optimal age at surgery in craniosynostosis continues to be debated. In addition, individuals with craniosynostosis may undergo reoperation to improve residual skull irregularities. It is unknown whether reoperation affects neuro-cognitive(More)
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