Christophe Vieu

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OBJECTIVES In the adult human brain, neurogenesis occurs in the SVZ and the dentate gyrus of the hippocampus, but it is still unclear whether persistent neural progenitor/stem cells are also present in other brain areas. The present work studies the possibility of obtaining neural progenitor/stem cells from the temporal lobe and investigates their potential(More)
With the ever increasing incidence of brain injury, developing new tissue engineering strategies to promote neural tissue regeneration is an enormous challenge. The goal of this study was to design and evaluate an implantable scaffold capable of directing neurite and axonal growth for neuronal brain tissue regeneration. We have previously shown in cell(More)
BACKGROUND A critical step in the fabrication of biochips is the controlled placement of probes molecules on solid surfaces. This is currently performed by sequential deposition of probes on a target surface with split or solid pins. In this article, we present a cost-effective procedure namely microcontact printing using stamps, for a parallel deposition(More)
Manganese-enhanced MRI (MEMRI) has been described as a powerful tool to depict the architecture of neuronal circuits. In this study we investigated the potential use of in vivo MRI detection of manganese for tracing neuronal projections from the primary motor cortex (M1) in healthy marmosets (Callithrix Jacchus). We determined the optimal dose of manganese(More)
Microstructured cell arrays are obtained by patterning of extracellular matrix (ECM) components on a substrate to control cell spread. Because such arrays are of interest to different fields related to cell biology, automatic production and parallelized assays are needed. With complete automation of ECM 2D patterning and whole-slide image acquisition, the(More)
A simple and versatile method for statistical analysis of the electrical properties of individual double walled carbon nanotubes. OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. A simple and versatile method for statistical analysis of the electrical properties of(More)
To investigate the respective roles of topography and cell/cell interactions in the development of a guided neuronal network on an engineered surface, micropatterned PDMS substrates were generated with different microgrooves geometry and investigated for the influence of cell density on neurite outgrowth and alignment. Through this systematic investigation,(More)
Multi-scale engineering for neuronal cell growth and differentiation. OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. a b s t r a c t In this paper we investigate the role of micropatterning and molecular coating for cell culture and differentiation of neuronal(More)
The wafer scale integration of carbon nanotubes (CNT) remains a challenge for electronic and electromechanical applications. We propose a novel CNT integration process relying on the combination of controlled capillary assembly and buried electrode dielectrophoresis (DEP). This process enables us to monitor the precise spatial localization of a high density(More)
Lysosome mobilization is a key cellular process in phagocytes for bactericidal activities and trans-matrix migration. The molecular mechanisms that regulate lysosome mobilization are still poorly known. Lysosomes are hard to track as they move toward phagosomes throughout the cell volume. In order to anticipate cell regions where lysosomes are recruited to,(More)