Christophe Luthy

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QUESTION UNDER STUDY Elderly patients represent an increasing proportion of emergency department (ED) admissions. When no specific complaint is identified, the reason for referral is commonly called "home care impossible". The aim of this study was to describe a population of elderly patients who present to the ED of a 1200-bed university hospital without(More)
Tramadol is a central analgesic with low affinity for opioid receptors. A major active metabolite (O-desmethyl-tramadol) shows a higher affinity for opioid receptors than tramadol. The influence of naloxone and quinidine (a selective P450DB1 or CAP2D6 inhibitor) on tramadol effect was investigated crossover and double-blind vs placebo in healthy subjects.(More)
To investigate the relation between age and HRQoL indicators in a community-dwelling population aged 65 years and older. Data were collected within a sample stratified by age (65–69; 70–74; 75–79; 80–84; 85–89; 90 years and above) and sex and randomly selected in the population records in Switzerland. The EQ-5D was used to assess HRQoL. Analyses were(More)
OBJECTIVE To explore the perception of dyspnoea in patients with severe chronic obstructive pulmonary disease. DESIGN Cross-sectional study using mixed methods. METHODS Thirty-two patients with severe chronic obstructive pulmonary disease were included. Data collected included 3 health-related quality of life questionnaires (SF-36, St George and Maugeri(More)
The mechanism of reversible and irreversible inhibition of thyroid peroxidase (TPO)-catalyzed iodination by thioureylene drugs was investigated using a model incubation system. The major observations may be summarized as follows. 1) TPO is inactivated by 1-methyl-2-mercaptoimidazole and propylthiouracil even in the presence of a relatively high(More)
OBJECTIVE Fibromyalgia (FM) is a chronic musculoskeletal pain disorder characterized by widespread pain. This study focuses on patients' attributions of illness and of symptom onset. METHODS Semi-structured interviews were conducted with 56 women to elicit patients' views on what triggered their FM. The transcripts of the interviews were analyzed using a(More)
In patients with chronic obstructive pulmonary disease (COPD), malnutrition and limited physical activity are very common and contribute to disease prognosis, whereas a balance between caloric intake and exercise allows body weight stability and muscle mass preservation. The goal of this review is to analyze the implications of chronic hypoxia on three key(More)
Cancer-related fatigue (CRF) is frequently overlooked. Adherence to treatment guidelines may be related to the patient’s views about illness. This study aimed at exploring patients’ views about CRF and determining whether they are congruent with best practice treatments. Data were collected in 160 consecutive patients hospitalized in a supportive care(More)
OBJECTIVES To assess residents' difficulties during the first year of residency. In contrast to previous studies that mainly used structured questionnaires, a qualitative procedure was applied. METHODS Twenty-four consecutive first-year residents in internal medicine were asked to "Please identify two to three major difficulties or concerns related to(More)