Christophe Le Clorennec

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Signal transducer and activator of transcription 1 (STAT1), a transcription factor known to participate in antiviral responses , acts as a tumor suppressor inhibiting cell growth and promoting apo-ptosis. To study the role of STAT1 in DNA damage–induced apoptosis in B lympho-cytes, its active form, STAT1␣, was specifically inhibited by the overexpression of(More)
Blockade of the human epidermal growth factor receptor 3 (HER3) and of the downstream phosphatidylinositide 3-kinase (PI3K)/AKT pathway is a prerequisite for overcoming drug resistance and to develop novel treatments for cancers that are not eligible for the currently approved targeted therapies. To this end, we generated specific antibodies (Abs) against(More)
We characterized the mechanism of action of the neuregulin-non-competitive anti-HER3 therapeutic antibody 9F7-F11 that blocks the PI3K/AKT pathway, leading to cell cycle arrest and apoptosis in vitro and regression of pancreatic and breast cancer in vivo. We found that 9F7-F11 induces rapid HER3 down-regulation. Specifically, 9F7-F11-induced HER3(More)
cycle arrest and apoptosis in human B-cells in Fludarabine-induced cell β and STAT1 α Differential roles of STAT1 (1930 articles) Signal Transduction (4217 articles) Neoplasia (4939 articles) Immunobiology (790 articles) Cell Adhesion and Motility (746 articles) Apoptosis Articles on similar topics can be found in the following Blood collections Information(More)
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