Christophe Hirtz

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A role for uncoupling protein-2 as a regulator of mitochondrial hydrogen peroxide generation.

Anne Nègre-Salvayre, Christophe Hirtz, +5 authors Louis Casteilla
FASEB journal : official publication of the…
1997

According to the state of mitochondrial respiration, the respiratory chain generates superoxide anions converted into hydrogen peroxide. Two uncoupling proteins (UCP) able to modulate the coupling… (More)

The B1-agonist [des-Arg10]-kallidin activates transcription factor NF-kappaB and induces homologous upregulation of the bradykinin B1-receptor in cultured human lung fibroblasts.

Joost Peter Schanstra, Emmanuelle Bataillé, +7 authors Jean Loup Bascands
The Journal of clinical investigation
1998

The bradykinin B1-receptor is strongly upregulated under chronic inflammatory conditions. However, the mechanism and reason are not known. Because a better understanding of the mechanism of the… (More)

Exocytosis and protein secretion in Trypanosoma

Anne Geiger, Christophe Hirtz, +6 authors Jean-Benoît Peltier
BMC Microbiology
2009

Human African trypanosomiasis is a lethal disease caused by the extracellular parasite Trypanosoma brucei. The proteins secreted by T. brucei inhibit the maturation of dendritic cells and their… (More)

Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity.

Nicolas R Barthélemy, François Fenaille, +8 authors François Becher
Journal of proteome research
2016

Tau protein plays a major role in neurodegenerative disorders, appears to be a central biomarker of neuronal injury in cerebrospinal fluid (CSF), and is a promising target for Alzheimer's disease… (More)

MS characterization of multiple forms of alpha-amylase in human saliva.

Christophe Hirtz, François Chevalier, +5 authors Dominique Deville de Périère
Proteomics
2005

Alpha-amylase is a major and well-characterized component of human saliva. Recent proteomic studies suggested that this protein could be observed in more than twenty spots on 2-D gels of salivary… (More)

Complexity of the human whole saliva proteome

Christophe Hirtz, Florian Chevalier, +4 authors Deville de Périère
Journal of Physiology and Biochemistry
2005

Recent characterization of the whole saliva proteome led to contradictory pictures concerning the complexity of its proteome. In this work, 110 proteins were analysed by mass spectrometry allowing… (More)

Absolute quantification of 35 plasma biomarkers in human saliva using targeted MS.

Christophe Hirtz, Jérôme Vialaret, Nora Nowak, Audrey Gabelle, Dominique Deville de Périère, Sylvain Lehmann
Bioanalysis
2016

BACKGROUND Although the use of human saliva for diagnosing disease has been known to be of great clinical potential, few attempts have been made so far to develop its use. In this work, we developed… (More)

Multi-omics profiling reveals that eating difficulties developed consecutively to artificial nutrition in the neonatal period are associated to specific saliva composition.

Martine Morzel, Eric Neyraud, +10 authors Gilles Feron
Journal of proteomics
2015

Prolonged enteral or parenteral nutrition in neonatal periods sometimes results in eating difficulties persisting for years, with reduced food intake through the oral route and thereby reduced… (More)

Towards a routine application of Top-Down approaches for label-free discovery workflows.

Pierre-Olivier Schmit, Jérôme Vialaret, +9 authors Christophe Hirtz
Journal of proteomics
2018

Thanks to proteomics investigations, our vision of the role of different protein isoforms in the pathophysiology of diseases has largely evolved. The idea that protein biomarkers like tau, amyloid… (More)

Quantitative Clinical Chemistry Proteomics (qCCP) using mass spectrometry: general characteristics and application.

Sylvain Lehmann, Andrew N Hoofnagle, +8 authors Christophe Hirtz
Clinical chemistry and laboratory medicine
2013

Proteomics studies typically aim to exhaustively detect peptides/proteins in a given biological sample. Over the past decade, the number of publications using proteomics methodologies has exploded.… (More)

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