Christophe C. Jouny

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OBJECTIVES One major subject of discussion in sleep studies is whether bursts of K-complexes (K-bursts) and delta waves (D-bursts), expressions of a subcortical arousal, truly reflect an arousal response during sleep. To address this question we studied the changes in heart rate (HR) during spontaneous arousals in healthy subjects. METHODS Twenty-seven(More)
PURPOSE Partial seizures (PSs) may be self-limited regional events or propagate further and secondarily generalize. The mechanisms and dynamics of secondarily generalized tonic-clonic seizures (GTCSs) are not well understood. Methods with which to assess the dynamic of those events are also limited. METHODS Seizures were analyzed from patients with(More)
The ultradian dynamics of the human waking EEG was studied using a short visual fixation task repeated every 10 min throughout the daytime. The EEG spectra obtained from the tasks were assessed for time effect and ultradian periodicity. Fronto-central EEG high frequency powers (22.5-44.5 Hz) decreased at the time of the midafternoon vigilance dip(More)
Over the last decade, the search for a method able to reliably predict seizures hours in advance has been largely replaced by the more realistic goal of very early detection of seizure onset, which would allow therapeutic or warning devices to be triggered prior to the onset of disabling clinical symptoms. We explore in this article the steps along the(More)
OBJECTIVE The study of epileptic electroencephalograph (EEG) dynamics can potentially provide insights into seizure onset, evolution and termination. We propose a new synthetic measure based on time-frequency decomposition to provide detailed characterization of these dynamic changes. METHODS The matching pursuit (MP) method allows for continuous(More)
PURPOSE The dynamics of partial seizures originating from neocortical and mesial temporal regions are thought to differ, yet there are no quantitative comparative studies. The studies reported here investigate the duration of complex partial seizures in these populations using analyses of seizures recorded from intracranial arrays. METHODS Data were(More)
OBJECTIVE Epileptic seizures are characterized by increases in synchronized activity and increased signal complexity. Prediction of seizures depends upon detectable preictal changes before the actual ictal event. The studies reported here test whether two methods designed to detect changes in synchrony and complexity can identify any changes in a preictal(More)
Debates on six controversial topics were held during the Fourth International Workshop on Seizure Prediction (IWSP4) convened in Kansas City, KS, USA, July 4-7, 2009. The topics were (1) Ictogenesis: Focus versus Network? (2) Spikes and Seizures: Step-relatives or Siblings? (3) Ictogenesis: A Result of Hyposynchrony? (4) Can Focal Seizures Be Caused by(More)
Paradoxical sleep (PS), in which periods with (phasic) and without (tonic) rapid eye movements are intermingled, is hypothesized to be related to cognitive processing and dreaming. Based on polysomnographic data from 12 healthy subjects, this study focuses on the spectral differentiation between phasic and tonic periods. Phasic PS periods exhibited(More)
OBJECTIVE We investigate the relevance of high frequency oscillations (HFO) for biomarkers of epileptogenic tissue and indicators of preictal state before complex partial seizures in humans. METHODS We introduce a novel automated HFO detection method based on the amplitude and features of the HFO events. We examined intracranial recordings from 33(More)