Christophe Badie

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Running title: Radiobiology and LEM predictions to high LET ions for HNSCC Acknowledgments: We thank all who participated in experiments at GANIL or GSI: Marie-Thérèse Aloy,Bodennec. We also thank Joel Rochat, Joseph Remillieux and Jacques Balosso for their continued assistance in accomplishing this work. We are grateful to the personnel of the 2(More)
In vivo transfer of wild-type (wt) p53 gene via a recombinant adenovirus has been proposed to induce apoptosis and increase radiosensitivity in several human carcinoma models. In the context of combining p53 gene transfer and irradiation, we investigated the consequences of adenoviral-mediated wtp53 gene transfer on the cell cycle and radiosensitivity of a(More)
Normal tissue reactions to radiation therapy vary in severity among patients and cannot be accurately predicted, limiting treatment doses. The existence of heritable radiosensitivity syndromes suggests that normal tissue reaction severity is determined, at least in part, by genetic factors and these may be revealed by differences in gene expression. To test(More)
The CBA/H mouse model of radiation-induced acute myeloid leukaemia (rAML) has been studied for decades to bring to light the molecular mechanisms associated with multistage carcinogenesis. A specific interstitial deletion of chromosome 2 found in a high proportion of rAML is recognised as the initiating event. The deletion leads to the loss of Sfpi, a gene(More)
Acute myeloid leukaemia (AML) is one of the most common malignancies seen to occur in human populations exposed to ionising radiation. 1 Mouse models have been widely used for quantitative and mechanistic studies of radiation leukaemogen-esis; further, there is a similarity in the histopathological changes found in human AML and mouse AML. The majority of(More)
The transcription factor PU.1, encoded by the murine Sfpi1 gene (SPI1 in humans), is a member of the Ets transcription factor family and plays a vital role in commitment and maturation of the myeloid and lymphoid lineages. Murine studies directly link primary acute myeloid leukaemia (AML) and decreased PU.1 expression in specifically modified strains.(More)
Exposure to ionising radiation can lead to an increased risk of cancer, particularly leukaemia. In radiation-induced acute myeloid leukaemia (rAML), a partial hemizygous deletion of mouse chromosome 2 is a common feature in several susceptible strains. The deletion is an early event detectable 24h after exposure in bone marrow cells using cytogenetic(More)
The goal of this study was to propose a method for meta-analysis of expression sets of single and dual channel intensity microarray data. This involved solving the issue of computational and biological consistency of the expression measures. We tested this approach on two sets from microarray data acquired in experiments performed to search for genetic(More)
The identification of polymorphisms and/or genes responsible for an organism's radiosensitivity increases the knowledge about the cell cycle and the mechanism of the phenomena themselves, possibly providing the researchers with a better understanding of the process of carcinogenesis. The aim of the study was to develop a data analysis strategy capable of(More)