Christophe Badie

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The goal of this study was to propose a method for meta-analysis of expression sets of single and dual channel intensity microarray data. This involved solving the issue of computational and biological consistency of the expression measures. We tested this approach on two sets from microarray data acquired in experiments performed to search for genetic(More)
The transcription factor PU.1, encoded by the murine Sfpi1 gene (SPI1 in humans), is a member of the Ets transcription factor family and plays a vital role in commitment and maturation of the myeloid and lymphoid lineages. Murine studies directly link primary acute myeloid leukaemia (AML) and decreased PU.1 expression in specifically modified strains.(More)
The identification of polymorphisms and/or genes responsible for an organism's radiosensitivity increases the knowledge about the cell cycle and the mechanism of the phenomena themselves, possibly providing the researchers with a better understanding of the process of carcinogenesis. The aim of the study was to develop a data analysis strategy capable of(More)
Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched for signatures of ionizing radiation in 12 radiation-associated second malignancies of different tumour types. Two signatures of(More)
Genome Wide Association Studies are often performed on datasets containing a relatively small number of genotypes. In those cases, statistical tests performed on subgroups of those genotypes lack power or may even not fulfill the requirements of minimal number of observations. In this work we present results of running a GWAS analysis including parametric(More)