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A t wo-dimensional nite-diierence model for elastic waves in the ground has been developed. The model uses the equation of motion and the stress-strain relation, from which a rst order stress-velocity f o r m ulation is obtained. The resulting system of equations is discretized using centered nite-diierences. A perfectly matched layer surrounds the(More)
BACKGROUND Orthostatic symptoms and syncope are common, even in apparently healthy subjects. In patients with severe autonomic dysfunction, water drinking elicits an acute pressor response and improves orthostatic hypotension. We tested the hypothesis that water drinking also improves orthostatic tolerance in healthy subjects. METHODS AND RESULTS In a(More)
BACKGROUND Agonistic autoantibodies directed at the alpha(1)-adrenergic receptor (alpha(1)-AAB) have been described in patients with hypertension. We implied earlier that alpha(1)-AAB might have a mechanistic role and could represent a therapeutic target. METHODOLOGY/PRINCIPAL FINDINGS To pursue the issue, we performed clinical and basic studies. We(More)
BACKGROUND Observations in patients with functional mutations of the norepinephrine transporter (NET) gene suggest that impaired norepinephrine uptake may contribute to idiopathic orthostatic intolerance. METHODS AND RESULTS We studied the effect of the selective NET blocker reboxetine and placebo in a randomized, double-blind, crossover fashion on(More)
BACKGROUND The overall effect of vasoactive drugs on blood pressure is determined by a combination of the direct effect on vascular tone and an indirect baroreflex-mediated effect, a baroreflex buffering of blood pressure. Differences in baroreflex function affect the responsiveness to vasoactive medications, particularly baroreflex buffering of blood(More)
BACKGROUND Sibutramine, a serotonin and norepinephrine transporter blocker, is widely used as an adjunctive obesity treatment. Norepinephrine reuptake inhibition with sibutramine conceivably could exacerbate arterial hypertension and promote cardiovascular disease. METHODS AND RESULTS In 11 healthy subjects (7 men, age 27+/-2 years, body mass index(More)
BACKGROUND Norepinephrine transporter (NET) inhibition increases the responsiveness to vasoactive medications and attenuates the response to sympathetic stimuli. The phenomenon may be a result of impaired regulation of sympathetic vasomotor tone. METHODS AND RESULTS We studied the effects of the selective NET blocker reboxetine and placebo on baroreflex(More)
Norepinephrine transporter (NET) function has a central role in the regulation of synaptic norepinephrine concentrations. Clinical observations in orthostatic intolerance patients suggest a gender difference in NET function. We compared the cardiovascular response to selective NET inhibition with reboxetine between 12 healthy men and 12 age-matched women.(More)
—A two-dimensional (2-D) finite-difference model for elastic waves in the ground has been developed. The model uses the equation of motion and the stress-strain relation, from which a first-order stress-velocity formulation is obtained. The resulting system of equations is discretized using centered finite-differences. A perfectly matched layer surrounds(More)