Christoph Sutter

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BACKGROUND The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity. (More)
BACKGROUND The TP53 pathway, in which TP53 and its negative regulator MDM2 are the central elements, has an important role in carcinogenesis, particularly in BRCA1- and BRCA2-mediated carcinogenesis. A single nucleotide polymorphism (SNP) in the promoter region of MDM2 (309T>G, rs2279744) and a coding SNP of TP53 (Arg72Pro, rs1042522) have been shown to be(More)
The authors present two cases of clinical brain death that failed to meet the criteria for whole brain death using Tc-99m HMPAO. Conventional anterior cerebral flow studies demonstrated no intracerebral perfusion. Anterior static images also failed to show cerebral activity. However, the lateral images clearly demonstrate cerebellar activity. These cases(More)
Projects under the Clean Development Mechanism (CDM) of the Kyoto Protocol shall assist countries in the developing world in achieving sustainable development. MATA-CDM (Multi-Attributive Assessment of CDM Projects) is a tool that facilitates a quantitative assessment of potential projects regarding their contribution to sustainable development. This report(More)
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