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Multiple lines of evidence implicate the basolateral amygdala (BLA) and the noradrenergic (norepinephrine, NE) system in responding to stressful stimuli such as fear signals, suggesting hyperfunction of both in the development of stress-related pathologies including anxiety disorders. However, no causative link between elevated NE neurotransmission and BLA(More)
Complement factor H (FH) attenuates C3b molecules tethered by their thioester domains to self surfaces and thereby protects host tissues. Factor H is a cofactor for initial C3b proteolysis that ultimately yields a surface-attached fragment (C3d) corresponding to the thioester domain. We used NMR and X-ray crystallography to study the C3d-FH19-20 complex in(More)
BACKGROUND Difficulties in prediction and early identification of (acute kidney injury) AKI have hindered the ability to develop preventive and therapeutic measures for this syndrome. We tested the hypothesis that a urine test measuring insulin-like growth factor-binding protein 7 (IGFBP7) and tissue inhibitor of metalloproteinases-2 (TIMP-2), both inducers(More)
Sign languages represent an interesting niche for statistical machine translation that is typically hampered by the scarceness of suitable data, and most papers in this area apply only a few, well-known techniques that are not adapted to small-sized corpora. In this article, we analyze existing data collections and emphasize their quality and usability for(More)
The first eight and the last two of 20 complement control protein (CCP) modules within complement factor H (fH) encompass binding sites for C3b and polyanionic carbohydrates. These binding sites cooperate self-surface selectively to prevent C3b amplification, thus minimising complement-mediated damage to host. Intervening fH CCPs, apparently devoid of such(More)
In text-to-avatar translation systems, facial expressions and mouth patterns are a vital part of a natural sign language avatar animation. However, gloss-based corpora often lack detail with respect to such non-manual features. To create a translation system which can produce facial expressions and mouthings, a more fine-grained annotation is necessary. In(More)
BACKGROUND All treatments of acute myocardial infarction are aimed at rapid revascularization of the occluded vessel; however, no clinical strategies are currently available to protect the heart from ischemia/reperfusion injury after restitution of blood flow. We hypothesized that some of the cholesterol transport-independent biological properties of(More)
Factor H autoantibodies have been reported in approximately 10% of patients with atypical hemolytic uremic syndrome (aHUS) and are associated with deficiency of factor H-related proteins 1 and 3. In this study we examined the prevalence of factor H autoantibodies in the Newcastle cohort of aHUS patients, determined whether the presence of such(More)
OBJECTIVE Aortic valve replacement for aortic valve stenosis (AS) and regurgitation (AR) in patients with severe left ventricular (LV) dysfunction contains an increased risk. Few data are available on the outcome of such patients. METHODS Fifty-five consecutive patients with severe LV dysfunction (ejection fraction, EF; <30%) and aortic valve replacement(More)
This paper introduces the RWTH-PHOENIX-Weather corpus, a video-based, large vocabulary corpus of German Sign Language suitable for statistical sign language recognition and translation. In contrast to most available sign language data collections, the RWTH-PHOENIX-Weather corpus has not been recorded for linguistic research but for the use in statistical(More)