Christoph Pohl

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OBJECTIVE To evaluate proton magnetic resonance spectroscopy for detection and monitoring of upper motoneuron degeneration in patients with amyotrophic lateral sclerosis. METHODS Seventy patients with amyotrophic lateral sclerosis according to the El Escorial criteria were compared with 48 healthy control subjects. Single-volume proton magnetic resonance(More)
 Proton magnetic resonance spectroscopy (1H-MRS) is a non-invasive method to investigate changes in brain metabolite composition in different cerebral diseases. We performed proton spectroscopy in patients with dementia of the Alzheimer's type (AD) and in patients with motor neuron disease (MND) with the aim to detect the specific metabolic pattern for(More)
OBJECTIVES To determine the motor cortex degeneration in patients with amyotrophic lateral sclerosis (ALS) using proton magnetic resonance spectroscopy, and to prove that proton magnetic resonance spectroscopy is suited to monitor the course of disease with follow-up examinations. MATERIALS AND METHODS We studied 33 patients with ALS whose conditions were(More)
BACKGROUND Prediction of susceptibility to multiple sclerosis (MS) might have important clinical applications, either as part of a diagnostic algorithm or as a means to identify high-risk individuals for prospective studies. We investigated the usefulness of an aggregate measure of risk of MS that is based on genetic susceptibility loci. We also assessed(More)
BACKGROUND Several controlled studies provide evidence that treatment with interferon beta in patients with a first event suggestive of multiple sclerosis (MS) delays conversion to clinically definite MS (CDMS). Our aim was to determine whether early initiation of treatment with interferon beta prevents development of confirmed disability in MS. METHODS(More)
BACKGROUND The Betaferon/Betaseron in newly emerging multiple sclerosis for initial treatment (BENEFIT) trial investigated the effect of treatment with interferon beta-1b after a clinically isolated syndrome. The 5-year active treatment extension compares the effects of early and delayed treatment with interferon beta-1b on time to clinically definite(More)
BACKGROUND The aim of the Betaferon Efficacy Yielding Outcomes of a New Dose (BEYOND) trial was to compare the efficacy, safety, and tolerability of 250 microg or 500 microg interferon beta-1b with glatiramer acetate for treating relapsing-remitting multiple sclerosis. METHODS Between November, 2003, and June, 2005, 2447 patients with relapsing-remitting(More)
The reliability of non-functional contracts is crucial for many software applications. This added to the increasing attention this issue lately received in software engineering. Another development in software engineering is toward component-based systems. The interaction of both, non-functional aspects and components, is a relatively new research area,(More)
OBJECTIVE This study examined whether extraction of particulate emboli using intra-aortic filtration could decrease neurologic outcomes. METHODS Patients (N = 582) were enrolled in a prospective, controlled study and alternately assigned to the therapy arm (n = 304; intra-aortic filtration) or control arm (n = 278). Preoperative, procedural, and(More)
Domain analysis involves not only looking at standard requirements documents (e.g., use case specifications) but also at customer information packs, market analyses, etc. Looking across all these documents and deriving, in a practical and scalable way, a feature model that is comprised of coherent abstractions is a fundamental and non-trivial challenge. We(More)