Christoph Melzer

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BACKGROUND High-cutoff hemofilters are characterized by an increased effective pore size designed to facilitate the elimination of inflammatory mediators in sepsis. This study compares diffusive versus convective high-cutoff renal replacement therapy (RRT) in terms of cytokine clearance rates and effects on plasma protein levels. METHODS Twenty-four(More)
BACKGROUND Cardiac Resynchronization Therapy (CRT) leads to a reduction of left-ventricular dyssynchrony and an acute and sustained hemodynamic improvement in patients with chronic heart failure. Furthermore, an optimized AV-delay leads to an improved myocardial performance in pacemaker patients. The focus of this study is to investigate the acute effect of(More)
sheet and exposed to atmosphere (i.e., without a cover), the solvent evaporates completely within 30 s. The film is floated onto water and picked up with a copper grid for TEM. Polyethylene comprises over 60 % of polyolefin production worldwide [1] and has widespread applications due to its high chemical resistance, low dielectric constant, and low cost.(More)
BACKGROUND Ritter's method is a tool used to optimize AV delay in DDD pacemaker patients with normal left ventricular function only. The goal of our study was to evaluate Ritter's method in AV delay-interval optimization in patients with reduced left ventricular function. METHODS Patients with implanted DDD pacemakers and AVB III degrees were assigned to(More)
BACKGROUND Intraseptal hematoma and subsequent myocardial infarction due to accidental contrast agent deposition complicating diagnostic cineventriculography is a previously undescribed complication of angiography. CASE PRESENTATION A 61 year old man was admitted at intensive care unit because of unstable angina pectoris 1 hour after coronary angiography.(More)
BACKGROUND Established methods to determine asynchrony suffer from high intra- and interobserver variability and failed to improve patient selection for cardiac resynchronization therapy (CRT). Thus, there is a need for easy and robust approaches to reliably assess cardiac asynchrony. METHODS AND RESULTS We performed echocardiography in 100 healthy(More)
AIMS Optimization of the AV-interval (AVI) in DDD pacemakers improves cardiac hemodynamics and reduces pacemaker syndromes. Manual optimization is typically not performed in clinical routine. In the present study we analyze the prevalence of E/A wave fusion and A wave truncation under resting conditions in 160 patients with complete AV block (AVB) under the(More)
BACKGROUND Cardiac resynchronization therapy (CRT) is generally associated with a low to moderate increase of the left ventricular ejection fraction (LVEF). In some patients, however, LVEF improves remarkably and reaches near-normal values. The aim of the present study was to further characterize these so called 'super-responders' with a special focus on(More)
BACKGROUND Cardiac resynchronization Therapy (CRT) is an effective therapy for chronic heart failure with beneficial hemodynamic effects leading to a reduction of morbidity and mortality. The responder rates, however, are low. There are various and contentious echocardiographic parameters of myocardial asynchrony. Patient selection by echocardiographic(More)
The phi-coefficient of an item in a multiple choice question (MCQ) examination is often used to determine whether that item is suitable for re-use in future examinations. In order to be of value in this regard, the coefficient must be shown to be an objective and consistent index of the discriminating power of an MCQ item. The behaviour of the(More)
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