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DNA methylation is the most stable type of epigenetic modification modulating the transcriptional plasticity of mammalian genomes. Using bisulfite DNA sequencing, we report high-resolution methylation profiles of human chromosomes 6, 20 and 22, providing a resource of about 1.9 million CpG methylation values derived from 12 different tissues. Analysis of(More)
The genome of Helicobacter pylori is remarkable for its large number of restriction-modification (R-M) systems, and strain-specific diversity in R-M systems has been suggested to limit natural transformation, the major driving force of genetic diversification in H. pylori. We have determined the comprehensive methylomes of two H. pylori strains at single(More)
Badly and inconsistently layouted business processes are hard to read for humans and therefore lack comprehensibility. Furthermore, processes generated by software have no layout at all. If stakeholders cannot comprehend the process descriptions, they are unable to validate them and ¿nd mistakes. By offering a fully automatic layout algorithm for BPMN, it(More)
BACKGROUND MYC is a key transcription factor involved in central cellular processes such as regulation of the cell cycle, histone acetylation and ribosomal biogenesis. It is overexpressed in the majority of human tumors including aggressive B-cell lymphoma. Especially Burkitt lymphoma (BL) is a highlight example for MYC overexpression due to a chromosomal(More)
In many real world applications simple classifiers are too weak to reach a pre-dictive power. Ensemble techniques, or mixture of experts, are a possible solution. We illustrate why mixtures of experts are a natural choice in domains as the prediction of environmental toxicity for chemical products, when a structural approach is pursued. The real data here(More)
Most quantitative structure-activity relationship (QSAR) models are linear relationships and significant for only a limited domain of compounds. Here we propose a data-driven approach with a flexible combination of unsupervised and supervised neural networks able to predict the toxicity of a large set of different chemicals while still respecting the QSAR(More)
We describe the characterization of the zebrafish homologue of the human gene DLG3. The zebrafish dlg3 gene encodes a membrane-associated guanylate kinase containing a single PDZ domain. This gene was cloned using a gene-trap construct inserted in the gene's first intron. The insertion co-segregates with a viable mutation called humpback (hmp), which leads(More)
Anti-Semitism continues to be a widespread societal problem rooted deeply in history. Using novel city-level data from Germany for more than 2,000 cities and county-level data, we study the role of economic incentives in shaping the coexistence of Jews, Catholics and Protestants. The Catholic ban on usury gave Jews living in Catholic regions a specific(More)